Showing 1-25 of 105 resultsfor "Index Terms":Hedgehog
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Differential SHH and IHH expression during osteogenesis induced by Dexamethasone in rat bone marrow mesenchymal cells
Xiaoli Ma;Shanshan Zu;Yanfei Jia;Yan Zheng;Shuyi Han;Hua Liu;Dongjie Xiao;Yunshan Wang;Xueping Zhang;Haiji Sun;Liguo An
2011 4th International Conference on Biomedical Engineering and Informatics (BMEI)
Year: 2011 | Conference Paper |
Hedgehog signaling pathway is an important signal pathway, which regulates the development of variety of tissues and organs in the embryonic stage. It also plays an important role in osteogenesis. However, there are few data recording the role of Hedgehog signaling molecules in osteogenic differentiation of bone marrow mesenchymal stem cells in vitro. Dexamethasone (DEX), a synthetic and widely us...Show More
Neural stem and progenitor cells have significant promise for the regeneration of tissue from the effects of trauma or neurodegenerative disorders, such as Alzheimer's or Parkinson's diseases. However, our understanding of the signaling factors and basic mechanisms that control their behavior must be greatly improved before this promise can be achieved. We have investigated the role of sonic hedge...Show More
Outlier Analysis and Top Scoring Pair for Integrated Data Analysis and Biomarker Discovery
Michael F. Ochs;Jason E. Farrar;Michael Considine;Yingying Wei;Soheil Meshinchi;Robert J. Arceci
Pathway deregulation has been identified as a key driver of carcinogenesis, with proteins in signaling pathways serving as primary targets for drug development. Deregulation can be driven by a number of molecular events, including gene mutation, epigenetic changes in gene promoters, overexpression, and gene amplifications or deletions. We demonstrate a novel approach that identifies pathways of in...Show More
Construction of GLI1 shRNA expression vector and effects on the proliferation of ovarian cancer cells
Li-Xia Wang;Jun Mao;Rong-Kuan Li;Ya-Jun Tao;Qiu-Ju Mou;Lian-Hong Li
2013 10th IEEE International Conference on Control and Automation (ICCA)
Year: 2013 | Conference Paper |
Ovarian cancer SKOV3 cells were transfected for 48 hours by the mediation of LipofectamineTM 2000. CCK-8 kit and real time RT-PCR were employed to evaluate the effects of GLI1 mRNA transfection on the proliferation of SKOV3 cells, the apoptosis rates induced by paclitaxel and the cell cycle of SKOV3 cells following the treatments were measured with flow cytometry; and cyclinD1 protein expression w...Show More
Drug Target Identification in Triple Negative Breast Cancer Stem Cell Pathways: A Computational Study of Gene Regulatory Pathways Using Boolean Networks
Aditya Lahiri;Haswanth Vundavilli;Madhurima Mondal;Pranabesh Bhattacharjee;Brian Decker;Giuseppe Del Priore;N. Peter Reeves;Aniruddha Datta
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer associated with an early age of onset, greater propensity towards metastasis, and poorer clinical outcomes. It accounts for 10% to 20% of newly diagnosed breast cancer cases and disproportionately affects individuals from the African American race. While TNBC is sensitive to chemotherapy, it is also prone to relapse. This ...Show More
Analyzing gene expression data for childhood medulloblastoma survival with artificial neural networks
2004 Symposium on Computational Intelligence in Bioinformatics and Computational Biology
Year: 2004 | Conference Paper |
Cited by: Papers (1)
One of the major problems facing gene expression researchers is how to reduce the high dimensionality of gene expression data in the face of small sample sizes in comparison to the number of genes measured. We report on the application of a single layer neural network for reducing the number of originally measured genes from over 7000 to 64 through repeated application of thresholds on the weights...Show More
Analyzing Gene Relationships for Down Syndrome with Labeled Transition Graphs
Neha Rungta;Hyrum Carroll;Eric G Mercer;Randall J. Roper;Mark Clement;Quinn Snell
Formal Methods in Computer Aided Design (FMCAD'07)
Year: 2007 | Conference Paper |
Cited by: Papers (1)
The relationship between changes in gene expression and physical characteristics associated with Down syndrome is not well understood. Chromosome 21 genes interact with nonchromosome 21 genes to produce Down syndrome characteristics. This indirect influence, however, is difficult to empirically define due to the number, size, and complexity of the involved gene regulatory networks. This work links...Show More
Integration of Significant Signaling Pathways Involved in Neural-fate Differentiation of Stem Cells
2023 10th International Conference on Computing for Sustainable Global Development (INDIACom)
Year: 2023 | Conference Paper |
The ability of stem cells to develop into functional neurons has been rigorously studied in the past several years. In the way of the interpretation of how the crosstalk between signaling pathways orchestrates the differentiation of stem cells into neuronal fate, this study has been carried out. Here, five major tracks viz. cAMP, MAPK, Wnt/β-catenin, Sonic Hedgehog (SHH), and Retinoic acid signali...Show More
M-NET: Transforming Single Nucleotide Variations Into Patient Feature Images for the Prediction of Prostate Cancer Metastasis and Identification of Significant Pathways
High-performance prediction of prostate cancer metastasis based on single nucleotide variations remains a challenge. Therefore, we developed a novel biologically informed deep learning framework, named M-NET, for the prediction of prostate cancer metastasis. Within the framework, we transformed single nucleotide variations into patient feature images that are optimal for fitting convolutional neur...Show More
The origin of the high-velocity circumstellar gas around SN 1998S
Modelling of high-resolution Balmer line profiles in the early-time spectra of SN 1998S shows that the inferred fast (≈400 km s−1) circumstellar (CS) gas on days 23 and 42 post-explosion is confined to a narrow, negative velocity gradient shell just above the photosphere. This gas may be identified with a slow (v<40 km s−1) progenitor wind accelerated at the ejecta—wind interface. In this scenario...Show More
Brian Runciman MBCS attended the first of a new type of BCS event in October 2015. It covered the very important subject, in line with BCS’s stated aim of making IT good for society, of the problems surrounding IT recruitment and capability. The discussion ranged from the principle of ‘try before you buy’, to hedgehogs and word bingo…Show More
Millimeter-Wave Dual Left/Right-Hand Circularly Polarized Beamforming Network
Mohammadmahdi Farahani;Mohammad Akbari;Mourad Nedil;Abdel-Razik Sebak;Tayeb A. Denidni
A novel high-efficiency eight-beams dual-polarized array antenna using an 8 × 8 beamforming network is studied and developed at 60 GHz. Two 4×4 Butler matrices are employed as base beamformers, and two 4×8 pattern control networks are utilized for increasing the number of radiating elements and suppressing sidelobes in the proposed dual left/right-hand circularly polarized (LH/RH CP) beamforming n...Show More
Blocker-Type Methods for Protecting Customers' Privacy in RFID Systems
Przemyslaw Blaskiewicz;Marek Klonowski;Krzysztof Majcher;Piotr Syga
2013 International Conference on Cyber-Enabled Distributed Computing and Knowledge Discovery
Year: 2013 | Conference Paper |
Cited by: Papers (3)
In this paper we present methods of protecting RFID tags users' privacy. Based on well-known technique by Juels et al. called Blocker tag we introduce a set of methods for increasing security using a device called Hedgehog blocker. Hedgehog blocker copes with the problem of the additional information gained by the adversary through measuring signal power (i.e. learning the number of transmitting t...Show More
Perturbed hedgehogs: continuous deformation of point defects in biaxial nematic liquid crystals
A spherically symmetric isolated point defect in a 3D uniaxial nematic liquid crystal sample is often called a radial hedgehog. We use topological methods to describe local configurations of uniaxial and biaxial states into which a hedgehog naturally deforms under small perturbations: these include the biaxial torus and split core configurations studied in the literature using analytical and numer...Show More
Simplified representation of vector fields
Proceedings Visualization '99 (Cat. No.99CB37067)
Year: 1999 | Conference Paper |
Vector field visualization remains a difficult task. Many local and global visualization methods for vector fields such as flow data exist, but they usually require extensive user experience on setting the visualization parameters in order to produce images communicating the desired insight. We present a visualization method that produces simplified but suggestive images of the vector field automa...Show More
4D space-time techniques: a medical imaging case study
Proceedings Visualization, 2001. VIS '01.
Year: 2001 | Conference Paper |
We present the problem of visualizing time-varying medical data. Two medical imaging modalities are compared-MRI and dynamic SPECT. For each modality, we examine several derived scalar and vector quantities such as the change in intensity over time, the spatial gradient, and the change of the gradient over time. We compare several methods for presenting the data, including isosurfaces, direct volu...Show More
Lateral Field Excitation (LFE) of Thickness Shear Mode (TSM) Acoustic Waves in Thin Film Bulk Acoustic Resonators (FBAR) as a Potential Biosensor
2006 International Conference of the IEEE Engineering in Medicine and Biology Society
Year: 2006 | Conference Paper |
Cited by: Papers (8)
Lateral field excitation (LFE) of a thin film bulk acoustic resonator (FBAR) is an ideal platform for biomedical sensors. A thickness shear mode (TSM) acoustic wave in a piezoelectric thin film is desirable for probing liquid samples because of the poor coupling of shear waves into the liquid. The resonator becomes an effective sensor by coating the surface with a bio- or chemi-specific layer. Per...Show More
Visualizing planar vector fields with normal component using line integral convolution
Proceedings Visualization '99 (Cat. No.99CB37067)
Year: 1999 | Conference Paper |
Cited by: Papers (8)
We present a method for visualizing three dimensional vector fields which are defined on a two dimensional manifold only. These vector fields do exist in real application, as we show by an example of an optical measuring instrument which can gauge the displacement at the surface of a mechanical part. The general idea is to compute LIC textures in the manifold's tangent space and to deform the mani...Show More
Automatic verification of Java design patterns
Proceedings 16th Annual International Conference on Automated Software Engineering (ASE 2001)
Year: 2001 | Conference Paper |
Cited by: Papers (7)
Design patterns are widely used by object oriented designers and developers for building complex systems in object oriented programming languages such as Java. However, systems evolve over time, increasing the chance that the pattern in its original form will be broken. We attempt to show that many design patterns (implemented in Java) can be verified automatically. Patterns are defined in terms o...Show More
CLIPS proceedings
2011 International Conference on Indoor Positioning and Indoor Navigation
Year: 2011 | Conference Paper |
This paper presents the latest developments related to an optical indoor positioning system named CLIPS, which consists of a projector and a mobile camera. With the projector, a pattern of laser spots is projected on any surface in an indoor environment. For the camera pose estimation in respect to the projector device, the camera has to capture the scene with the laser spots. The geometric relati...Show More
Vector fields can represent magnetic, electrical, fluid, and gas velocity fields in engineering applications, as well as various displacement and strain fields. They implicitly contain a large amount of data not directly or easily observable. Computer graphics has several techniques to assist scientists and engineers in understanding the phenomena behind the analyzed data. The paper discusses a te...Show More
Quadrupedal mammal locomotion dynamics 2D model
Proceedings. 2000 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2000) (Cat. No.00CH37113)
Year: 2000 | Conference Paper |
Cited by: Papers (5)
Making a quadrupedal robotic machine walk is a problem with an infinity of solutions. Nevertheless, this question seems to have been solved successfully by mammals. Hence a particular approach in the design of walking robots has been considered, based on the animals movement characteristics. Indeed, studying animal walking can help produce a class of solutions towards the definition of quadrupedal...Show More
Diary-Like Long-Term Activity Recognition: Touch or Voice Interaction?
Philipp M. Scholl;Marko Borazio;Martin Jansch;Kristof Van Laerhoven
2014 11th International Conference on Wearable and Implantable Body Sensor Networks Workshops
Year: 2014 | Conference Paper |
Cited by: Papers (3)
The experience sampling methodology is a well known tool in psychology to asses a subject's condition. Regularly or whenever an important event happens the subject stops whatever he is currently involved in and jots down his current perceptions, experience, and activities, which in turn form the basis of these diary studies. Such methods are also widely in use for gathering labelled data for weara...Show More
Understanding the Behavior of SnAg Bumps at 10 µm Pitch and Below for Imaging and Microdisplay Application
D. Taneja;M. Volpert;G. Lasfargues;T. Catelain;D. Henry;F. Hodaj
2016 IEEE 66th Electronic Components and Technology Conference (ECTC)
Year: 2016 | Conference Paper |
Cited by: Papers (3)
The finer pitch of 10 μm and below is currently explored by Microdisplays and Imaging industries. There are many contenders for achieving assembly at this pitch e.g. Cu-diffusion, Microtubes[1], and SnAg bumps. Among the contenders, SnAg bumps are tested for larger bumps but their capabilities for the finer pitch are yet to be explored. In this paper, behavior of SnAg for smaller bumps for the fin...Show More
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