With Covid-19, a significant proportion of the population who are already vaccinated have tested positive. Therefore, there is a need for better medicines that act against the virus rigorously without causing any side effects. We aim to achieve the same through molecular docking and further simulations for bioactive phytochemicals of ayurvedic medicinal plants. The target for this study has been c...Show More
The ability of stem cells to develop into functional neurons has been rigorously studied in the past several years. In the way of the interpretation of how the crosstalk between signaling pathways orchestrates the differentiation of stem cells into neuronal fate, this study has been carried out. Here, five major tracks viz. cAMP, MAPK, Wnt/β-catenin, Sonic Hedgehog (SHH), and Retinoic acid signali...Show More
Asthma is a chronic inflammatory disease by which, about 300 million people are affected worldwide. Response of most of asthmatic individuals is well to the currently available treatments of inhaled corticosteroids and beta-adrenergic agonists, however, 5-10% who has severe disease responds poorly. Addressing these challenges requires identification of novel drugs, development of non-invasive and ...Show More
Computational drug designing represents a new approach towards drug discovery. In this study, structure based drug design was used to find an antibiofilm agent to suppress Pseudomonas aeruginosa biofilm production in venous catheters and artificial hip prosthesis. PelD protein was chosen as a target protein for this process as it dominates exopolysaccharide matrix formation and compactness of biof...Show More
