Cortical organoids are rapidly emerging as models for brain development and dysfunction because they bridge the benefits of physiological manipulability of in vitro cultures with the complexity of in vivo brains. Organoids offer a host of benefits including the ability to perform patient-specific drug screening, study brain development, and investigate disease. Another promising application of org...Show More
Neural stem and progenitor cells have significant promise for the regeneration of tissue from the effects of trauma or neurodegenerative disorders, such as Alzheimer's or Parkinson's diseases. However, our understanding of the signaling factors and basic mechanisms that control their behavior must be greatly improved before this promise can be achieved. We have investigated the role of sonic hedge...Show More
