Showing 1-25 of 583 resultsfor "Index Terms":optogenetics
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Optical fiber technologies for in-vivo light delivery and optogenetics
Leonardo Sileo;Marco Pisanello;Andrea Della Patria;Mohamed S. Emara;Ferruccio Pisanello;Massimo De Vittorio
2015 17th International Conference on Transparent Optical Networks (ICTON)
Year: 2015 | Conference Paper |
Cited by: Papers (8)
In optogenetics, light-sensitive proteins are genetically targeted into specific classes of neurons in living animal models (typically mice), making possible to control their neural activity by means of visible light delivered into the brain tissue. In this paper, recent advances on techniques for in-vivo optical stimulation and inhibition of neuronal activity in optogenetic experiments are report...Show More
A Compact Wireless Headstage based Optogenetic Neuromodulation and 32-channel Electrophysiological Recording System
2023 IEEE 16th Dallas Circuits and Systems Conference (DCAS)
Year: 2023 | Conference Paper |
Cited by: Papers (1)
This paper demonstrates a commercial off-the-shelf components (COTS)-based miniaturized wireless optogenetic headstage with simultaneous optical stimulation and electro-physiological recording capability for freely moving rodents. The proposed headstage contains 32 recording channels. The optical stimulation system is a battery-powered neural stimulator, comprised of a low dropout regulator (LDO),...Show More
Enhanced peripheral motor responses mediated by spatiotemporal patterning of optogenetic nerve stimulation
2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Year: 2024 | Conference Paper |
Optogenetic stimulation of peripheral motor nerves offers several attractive properties for stimulation of muscle activity. One drawback of this approach is that the relatively slow channel kinetics of standard opsins such as channel-rhodopsin2 (ChR2) limit the frequency of stimulation trains that may be used compared to traditional electrical stimulation approaches. However, propagation of light-...Show More
Cortical Hemodynamic Response to Multi-afferent Stimulation: an optical imaging study
2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Year: 2020 | Conference Paper |
Multisensory stimulation plays an important role in the recovery of ischemic stroke. However, little is known about the interactions between neuronal activities with multi-afferent stimulations and their effects on hemodynamic responses. Optogenetics has been a useful tool in neuroscience research to unravel the mechanisms of neurovascular coupling at cell-specific level. In this study, we applied...Show More
Development of a Power Supply for Optogenetic Devices Used in Continuous Mouse Experiments with Renal Sympathetic Nerve Stimulation
Yuri Kabashima;Yoichi Ishizuka;Tsuyoshi Inoue;Ryusuke Umene;Yuichiro Shibata;Tomohiro Furusato;Eri Sakuda;Gen Onodera
2024 13th International Conference on Renewable Energy Research and Applications (ICRERA)
Year: 2024 | Conference Paper |
Chronic kidney disease (CKD) is a growing global health issue with no fundamental cure, prompting the need for innovative treatment approaches. In this context, our research, in collaboration with medical doctors and co-researchers, focuses on the protective effects of sympathetic nerve stimulation in the kidneys, aiming to develop new therapeutic strategies. Traditional methods, such as pharmacol...Show More
Electrophysiology-Based Closed Loop Optogenetic Brain Stimulation Devices: Recent Developments and Future Prospects
With its potential of single cell specificity, optogenetics has made the investigation into the brain circuits more controllable. Closed loop optogenetic brain stimulation enhances the efficacy of the stimulation by adjusting the stimulation parameters based on direct feedback from the target area of the brain. It combines the principles of genetics, physiology, electrical engineering, optics, sig...Show More
A System-on-Chip for Closed-loop Optogenetic Sleep Modulation
2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Year: 2021 | Conference Paper |
Cited by: Papers (7)
Stimulation of target neuronal populations using optogenetic techniques during specific sleep stages has begun to elucidate the mechanisms and effects of sleep. To conduct closed-loop optogenetic sleep studies in untethered animals, we designed a fully integrated, low-power system-on-chip (SoC) for real-time sleep stage classification and stage-specific optical stimulation. The SoC consists of a 4...Show More
Timing is Everything: Stochastic Optogenetic Stimulation Reduces Adaptation in Retinal Ganglion Cells
William C. Kwan;Emma K. Brunton;James M. Begeng;Rachael T. Richardson;Michael R. Ibbotson;Wei Tong
2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Year: 2023 | Conference Paper |
Optogenetics gives us unprecedented power to investigate brain connectivity. The ability to activate neural circuits with single cell resolution and its ease of application has provided a wealth of knowledge in brain function. More recently, optogenetics has shown tremendous utility in prosthetics applications, including vision restoration for patients with retinitis pigmentosa. One of the disadva...Show More
Simultaneous high-density 512-channel SiNAPS electrical recordings and optogenetics
Gabor Orban;Alberto Perna;Matteo Vincenzi;Alessandro Caltabiano;Luca Nava;Raffaella Tonini;Gian Nicola Angotzi;João F. Ribeiro;Luca Berdondini
2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Year: 2024 | Conference Paper |
The experimental use of CMOS high-density neural probes enables the wide field observation of the electrical activity of neural circuits at the resolution of single neurons. Optogenetic light stimulation allows to control and modulate the activity of neural cells, in a genetically selective manner. The combination of these techniques can be a powerful approach for investigating mechanisms of brain...Show More
Optogenetic Locus Coeruleus Stimulation Improves Pupil Size Tracking of Cortical State
2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Year: 2024 | Conference Paper |
Brain state heavily influences our perception, cognition, and behavior. Multiple neuromodulatory systems, including the locus coeruleus - norepinephrine (LC-NE) system, contribute to the regulation of brain state. This research harnesses machine learning and optogenetics technologies to probe the impact of the LC on cortical state and pupillary responses in awake mice. Our integrative approach com...Show More
Wireless Multimodal Neural Interface Device for Neural Control Studies
2021 IEEE Biomedical Circuits and Systems Conference (BioCAS)
Year: 2021 | Conference Paper |
Cited by: Papers (2)
We present a wireless multimodal neural interface device to record neural activities of neurons in dorsal root ganglia (DRG) and muscle electrical activities (EMG) of the selected muscles of 4 limbs, while selectively manipulating neural activities in DRGs of freely locomoting cats via optogenetic stimulation. The neural interface device has 4 identical 8-channel analog front-end (AFE) circuits fo...Show More
An Adaptive and Autonomous System-On-Chip with Data Analysis for μs-Latency Closed-Loop Optogenetics
2023 IEEE Biomedical Circuits and Systems Conference (BioCAS)
Year: 2023 | Conference Paper |
In this paper, we report a mixed-signal chip in 0.13-μm designed for long term autonomous operation that can trigger low-latency stimulation upon the detection of complex neural firing patterns. This adaptive autonomous neural IC (AANIC) includes: i) circuits for multi-site optogenetics stimulation and multi-unit electrophysiology recording, ii) specialized digital cores to detect, compress, and c...Show More
An Engineering Platform for Clinical Application of Optogenetic Therapy in Retinal Degenerative Diseases
Optogenetics is a new approach for controlling neural circuits with numerous applications in both basic and clinical science. In retinal degenerative diseases, the photoreceptors die, but inner retinal cells remain largely intact. By expressing light sensitive proteins in the remaining cells, optogenetics has the potential to offer a novel approach to restoring vision. In the past several years, o...Show More
An Integrated Circuit for Simultaneous Extracellular Electrophysiology Recording and Optogenetic Neural Manipulation
Chang Hao Chen;Elizabeth A. McCullagh;Sio Hang Pun;Peng Un Mak;Mang I Vai;Pui In Mak;Achim Klug;Tim C. Lei
Objective: The ability to record and to control action potential firing in neuronal circuits is critical to understand how the brain functions. The objective of this study is to develop a monolithic integrated circuit (IC) to record action potentials and simultaneously control action potential firing using optogenetics. Methods: A low-noise and high input impedance (or low input capacitance) neura...Show More
A Wireless Electro-Optic Headstage With a 0.13-${\mu}$m CMOS Custom Integrated DWT Neural Signal Decoder for Closed-Loop Optogenetics
Gabriel Gagnon-Turcotte;Iason Keramidis;Christian Ethier;Yves De Koninck;Benoit Gosselin
We present a wireless electro-optic headstage that uses a 0.13-μm CMOS custom integrated circuit (IC) implementing a digital neural decoder (ND-IC) for enabling real-time closed-loop (CL) optogenetics. The ND-IC processes the neural activity data using three digital cores: 1) the detector core detects and extracts the action potential (AP) of individual neurons by using an adaptive threshold; 2) t...Show More
An Integrated μLED Optrode for Optogenetic Stimulation and Electrical Recording
In this letter, we developed an integrated neural probe prototype for optogenetic stimulation by microscale light-emitting diode (μLED) and simultaneous recording of neural activities with microelectrodes on a single-polyimide platform. Optogenetics stimulates in vivo neural circuits with high-cellular specificity achieved by genetic targeting and precise temporal resolution by interaction of ligh...Show More
Optogenetic Brain Interfaces
Ramin Pashaie;Polina Anikeeva;Jin Hyung Lee;Rohit Prakash;Ofer Yizhar;Matthias Prigge;Divya Chander;Thomas J. Richner;Justin Williams
The brain is a large network of interconnected neurons where each cell functions as a nonlinear processing element. Unraveling the mysteries of information processing in the complex networks of the brain requires versatile neurostimulation and imaging techniques. Optogenetics is a new stimulation method which allows the activity of neurons to be modulated by light. For this purpose, the cell-types...Show More
NOise Reduction with DIstribution Corrected (NORDIC) PCA improves signal-to-noise in rodent resting-state and optogenetic functional MRI
Russell W. Chan;Royce P. Lee;Sarah Y. Wu;Emily L. Tse;Yixi Xue;Steen Moeller;Kevin C. Chan
2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Year: 2022 | Conference Paper |
NOise Reduction with DIstribution Corrected (NORDIC) principal component analysis (PCA) has been shown to selectively suppress thermal noise and improve temporal signal-to-noise ratio (tSNR) in human functional magnetic resonance imaging (fMRI). However, the feasibility to improve rodent fMRI using NORDIC PCA has not been explored. In this study, we developed a rodent fMRI preprocessing pipeline b...Show More
Wirelessly Powered 3-D Printed Headstage Based Neural Stimulation System for Optogenetic Neuromodulation Application
This work presents a miniaturized wireless power transfer (WPT) system integrated with a neuromodulation headstage for duty-cycled optical stimulation of freely moving rodents. The proposed WPT system is built using the commercially available off-the-shelf components (COTS) for the optogenetic neuromodulation system consisting of a bridge rectifier, a DC-DC converter, an oscillator circuit, an LED...Show More
Ultrasonically Powered and Controlled Microsystem for Dual-Wavelength Optogenetics With a Multiload Regulation Scheme
Amin Rashidi;Milad Zamani;Tanmay Mondal;Seyedsina Hosseini;Kjeld Laursen;Brian Corbett;Farshad Moradi
This letter presents an ultrasonically powered dual-wavelength optogenetic device that targets simultaneous excitation and inhibition of neural activities, or in a broader sense, optical stimulation in two distinct wavelengths for targeting different populations of neurons. This can be applied to a variety of neurological disorders. The device features a load regulator circuit that shares the avai...Show More
Flexible Polymer Optical Waveguides for Integrated Optogenetic Brain Implants
Julian A. Singer;Till Stramm;Jens Fasel;Oliver Schween;Anton Gelaeschus;Andreas Bahr;Matthias Kuhl
2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS)
Year: 2023 | Conference Paper |
Cited by: Papers (4)
This paper presents a manufacturing process for flexible optical waveguides made of biocompatible polydimethylsiloxane (PDMS) to be attached to future optogenetic implants. Based on a complementary metal-oxide-semiconductor (CMOS) application-specific integrated circuit (ASIC), the system uses integrated single photon avalanche diodes (SPADs) as sensors for fluorescence imaging (FI) and post-CMOS ...Show More
Nanomachined tapered optical fibers for in vivo optogenetics
Ferruccio Pisanello;Leonardo Sileo;Marco Pisanello;Andrea Della Patria;Massimo De Vittorio;Ian A. Oldenburg;Bernardo L. Sabatini;Marco Pisanello;Massimo De Vittorio;John A. Assad
2015 IEEE 15th International Conference on Nanotechnology (IEEE-NANO)
Year: 2015 | Conference Paper |
Cited by: Papers (4)
The advent of new methods to optically trigger neural activity has increased the demand for new techniques to deliver light into the brain. However, currently available technologies are limited by the overall invasiveness of optical neural implants. In this work we present a new and minimally invasive technology based on tapered, metal-coated and nanostructured optical fibers, allowing for the cus...Show More
An Ultrasonically-Powered System for 1.06 mm3 Implantable Optogenetics and Drug Delivery Dust
Kjeld Laursen;Milad Zamani;Yasser Rezaeiyan;Seyedsina Hosseini;Tanmay Mondal;Brian Corbett;Abdel Mouttalib Ouagazzal;Marianne Amalric;Farshad Moradi
This brief presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode $(\mu $ LED) integrated, miniaturized, and...Show More
Estimating and Analyzing Neural Information flow using Signal Processing on Graphs
Felix Schwock;Julien Bloch;Les Atlas;Shima Abadi;Azadeh Yazdan-Shahmorad
ICASSP 2023 - 2023 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)
Year: 2023 | Conference Paper |
Cited by: Papers (1)
Correlating neural communication in brain networks with behavior and cognition can provide fundamental insights into the functionality of both healthy and diseased brains. We demonstrate how communication in the brain can be estimated from recorded neural activity using concepts from graph signal processing. The communication is modeled as a flow signals on the edges of a graph and naturally arise...Show More
The study of C. elegans responses to external stimuli is crucial for understanding their locomotion patterns. Common stimuli include optogenetic stimulation, electrical stimulation, and chemical stimulation. Investigating the locomotion responses of C. elegans to these stimuli helps scientists understand how the nervous system integrates external signals to produce appropriate motor responses. How...Show More
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