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Neurovascular Coupling Impairment in Acute Ischemic Stroke by Optogenetics and Optical Brain Imaging
2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Year: 2020 | Conference Paper |
Cited by: Papers (2)
The coupling between neuronal activity and cerebral blood flow (CBF), known as neurovascular coupling, has been reported to be impaired after stroke. This study aims to investigate the neurovascular coupling impairment at the acute stage after ischemic stroke. Laser speckle contrast imaging (LSCI) was applied to measure the hemodynamic response to optogenetic excitation of sensorimotor neurons in ...Show More
Cortical Hemodynamic Response to Multi-afferent Stimulation: an optical imaging study
2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Year: 2020 | Conference Paper |
Multisensory stimulation plays an important role in the recovery of ischemic stroke. However, little is known about the interactions between neuronal activities with multi-afferent stimulations and their effects on hemodynamic responses. Optogenetics has been a useful tool in neuroscience research to unravel the mechanisms of neurovascular coupling at cell-specific level. In this study, we applied...Show More
Optogenetic Excitation of Ipsilesional Sensorimotor Neurons is Protective in Acute Ischemic Stroke: A Laser Speckle Imaging Study
Objective: Directly modulating targeted cortical function, brain stimulation provides promising techniques for stroke intervention. However, the cellular level mechanisms underlying preserved neurovascular function remains unclear. Optogenetics provides a cell-specific approach to modulate the neuronal activity. This study aims to investigate whether the exclusive excitation of sensorimotor neuron...Show More
Hemodynamic response to optogenetic stimulation varied under different stimulus parameters
2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Year: 2017 | Conference Paper |
Cited by: Papers (3)
The coupling between neuronal activity and cerebral blood flow(CBF), known as neurovascular coupling, serves as the basis of functional brain imaging. Optogenetics provides a precise and selective approach to manipulate the activity in cell-specific neurons. It has been used in neuroscience research for comprehensive understanding about the light-evoked neurovascular coupling in rodent neuronal ci...Show More
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