Loading [MathJax]/extensions/MathMenu.js
Lateral Field Excitation (LFE) of Thickness Shear Mode (TSM) Acoustic Waves in Thin Film Bulk Acoustic Resonators (FBAR) as a Potential Biosensor | IEEE Conference Publication | IEEE Xplore

Lateral Field Excitation (LFE) of Thickness Shear Mode (TSM) Acoustic Waves in Thin Film Bulk Acoustic Resonators (FBAR) as a Potential Biosensor


Abstract:

Lateral field excitation (LFE) of a thin film bulk acoustic resonator (FBAR) is an ideal platform for biomedical sensors. A thickness shear mode (TSM) acoustic wave in a ...Show More

Abstract:

Lateral field excitation (LFE) of a thin film bulk acoustic resonator (FBAR) is an ideal platform for biomedical sensors. A thickness shear mode (TSM) acoustic wave in a piezoelectric thin film is desirable for probing liquid samples because of the poor coupling of shear waves into the liquid. The resonator becomes an effective sensor by coating the surface with a bio- or chemi-specific layer. Perturbations of the surface can be detected by monitoring the resonance condition. Furthermore, FBARs can be easily fabricated to operate at higher frequencies, yielding greater sensitivity. An array of sensors offers the possibility of redundancy, allowing for statistical decision making as well as immediate corroboration of results. Array structures also offer the possibility of signature detection, by monitoring multiple targets in a sample simultaneously. This technology has immediate application to cancer and infectious disease diagnostics and also could serve as a tool for general proteomic research
Date of Conference: 30 August 2006 - 03 September 2006
Date Added to IEEE Xplore: 15 December 2016
Print ISBN:1-4244-0032-5
Print ISSN: 1557-170X
PubMed ID: 17946254
Conference Location: New York, NY, USA
References is not available for this document.

Introduction

Most experts agree that early detection is a key component to combating many of today's greatest public health threats. Biomolecular markers are present in individuals that suffer from cancer, tuberculosis, HIV / AIDS, hepatitis and malaria even at the earliest stages of development. The primary barrier to early detection is insufficient diagnostic processes. A detection mechanism exhibiting extremely high sensitivity and selectivity is required to identify the telling compounds that could indicate the development of a condition. Moreover, it is critical that such a detection mechanism have a process for minimizing reports of false positives or negatives. Most diagnostic procedures today require immunological lab equipment and trained medical staff to perform the procedures. This is expensive, often to the point of being impracticable, and often there is a significant delay in obtaining results. Current techniques become increasingly unfeasible for many applications that involve screening a large number of patients. The solution to these problems is to employ available technology to make cheaper and more accurate diagnostic equipment that improves and shortens the decision making process while also requiring minimal training or expertise.

Select All
1.
A. Shons, F. Dorman, J. Najarian, "An immunospecific microbalance" J Biomed Mater Res 6 (6): 565-570. 1972
2.
S.F. Chou, W.L. Hsu, J.M. Hwang, C.Y. Chen, "Determination of alpha-fetoprotein in human serum by a quartz crystal microbalance-based immunosensor" Clinical Chemistry 48: 913-918, 2002
3.
Z.Y. Wu, G.L. Shen, S.P. Wang, R.Q. Yu, "Quartz-crystal microbalance immunosensor for Schistsoma-japonicum-infected rabbit serum" Anal Sci 19(3): 437-440, 2003
4.
X.L. Su, Y. Li, "A self-assembled monolayer-based piezoelectric immunosensor for rapid detection of Escherichia coli 0157:H7" Biosens Bioelectron 19(6): 563-574, 2004
5.
J. Rosenbaum, Bulk Acoustic Wave Theory and Devices, Artech House, Inc 1988
6.
B.A. Auld, Acoustic Fields and Waves in Solids, Krieger Publishing Co. Vol 1 Apdx B, 1973
7.
D.M. Gersten, J.J. Marchalonis, "A rapid, novel method for the solid-phase derivatization of IgG antibodies for immune-affinity chromatography" J Immunol Methods 24(3-4): 305-9, 1978
8.
C.D. Corso, D.D. Stubbs, S.H. Lee, M. Goggins, R.H. Hruban, W.D. Hunt, "Real-time detection of mesothelin in pancreatic cancer cell line supernatant using an acoustic wave immunosensor" Cancer Det Prev 30: 180-87, 2006
9.
G. Sauerbrey, "Use of vibrating quartz for thin film weighing and microweighing" (in German) Z. Phys 155: 206-222, 1959
10.
K.K. Kanazawa, J.G. Gordon, "The Oscillation Frequency of a Quartz Resonator in Contact With a Liquid" Anal. Chim. Acta 175: 99-105, 1985
11.
W.D. Hunt, D.D. Stubbs, S.H. Lee, "Time-Dependent Signatures of Acoustic Wave Biosensors" Proc. IEEE 91: 890-901, 2003
12.
C.D. Corso, A. Dickherber, P. Shah, A Migdal, M.W. Datta, S. Datta, W.D. Hunt, "Development of Simple Inexpensive BAW Nanosensor for Cancer Biomarkers: Detection of Secreted SHH from Prostate Cancer Cells", (Poster) American Association of Cancer Researchers Annual Meeting 2006, Washington DC, April 2-5, 2
Contact IEEE to Subscribe

References

References is not available for this document.