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Lateral Field Excitation (LFE) of Thickness Shear Mode (TSM) Acoustic Waves in Thin Film Bulk Acoustic Resonators (FBAR) as a Potential Biosensor | IEEE Conference Publication | IEEE Xplore

Lateral Field Excitation (LFE) of Thickness Shear Mode (TSM) Acoustic Waves in Thin Film Bulk Acoustic Resonators (FBAR) as a Potential Biosensor


Abstract:

Lateral field excitation (LFE) of a thin film bulk acoustic resonator (FBAR) is an ideal platform for biomedical sensors. A thickness shear mode (TSM) acoustic wave in a ...Show More

Abstract:

Lateral field excitation (LFE) of a thin film bulk acoustic resonator (FBAR) is an ideal platform for biomedical sensors. A thickness shear mode (TSM) acoustic wave in a piezoelectric thin film is desirable for probing liquid samples because of the poor coupling of shear waves into the liquid. The resonator becomes an effective sensor by coating the surface with a bio- or chemi-specific layer. Perturbations of the surface can be detected by monitoring the resonance condition. Furthermore, FBARs can be easily fabricated to operate at higher frequencies, yielding greater sensitivity. An array of sensors offers the possibility of redundancy, allowing for statistical decision making as well as immediate corroboration of results. Array structures also offer the possibility of signature detection, by monitoring multiple targets in a sample simultaneously. This technology has immediate application to cancer and infectious disease diagnostics and also could serve as a tool for general proteomic research
Date of Conference: 30 August 2006 - 03 September 2006
Date Added to IEEE Xplore: 15 December 2016
Print ISBN:1-4244-0032-5
Print ISSN: 1557-170X
PubMed ID: 17946254
Conference Location: New York, NY, USA
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Introduction

Most experts agree that early detection is a key component to combating many of today's greatest public health threats. Biomolecular markers are present in individuals that suffer from cancer, tuberculosis, HIV / AIDS, hepatitis and malaria even at the earliest stages of development. The primary barrier to early detection is insufficient diagnostic processes. A detection mechanism exhibiting extremely high sensitivity and selectivity is required to identify the telling compounds that could indicate the development of a condition. Moreover, it is critical that such a detection mechanism have a process for minimizing reports of false positives or negatives. Most diagnostic procedures today require immunological lab equipment and trained medical staff to perform the procedures. This is expensive, often to the point of being impracticable, and often there is a significant delay in obtaining results. Current techniques become increasingly unfeasible for many applications that involve screening a large number of patients. The solution to these problems is to employ available technology to make cheaper and more accurate diagnostic equipment that improves and shortens the decision making process while also requiring minimal training or expertise.

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