Abstract:
A reflection-type hybrid optical sensor was designed for continuous measurement of both hemoglobin content ((Hb)) and oxygen saturation (OS) of whole blood. The sensor wa...Show MoreMetadata
Abstract:
A reflection-type hybrid optical sensor was designed for continuous measurement of both hemoglobin content ((Hb)) and oxygen saturation (OS) of whole blood. The sensor was based on a theoretical model using the photon diffusion theory. The prototype sensor consists of a light emitting diode (LED) and photodiode chips mounted on a single substrate and cased in a TO-5 can with its surface covered with clear epoxy resin. The effect of hematocrit variation was eliminated. It was test in goat, calf, and human whole blood over hematocrit range of 20-45%. The modified ratio method reduced the effect of hematocrit variation of hemoglobin OS measurement with improvement in standard deviation of errors from about 7.0 to 2.0%. The standard errors in the estimation of hemoglobin content ranged from 1.5 to 0.5 gm%. The oxygen contents of whole blood derived from the prototype sensor correlated well (r=0.997) with those analyzed using a hemoximeter. The prototype sensors have been used for continuous measurement of oxygen delivery to, and oxygen consumption by, peripheral tissues in artificial heart animals for a duration of 40 days, demonstrating satisfactory performance.<>
Published in: IEEE Transactions on Biomedical Engineering ( Volume: 35, Issue: 3, March 1988)
DOI: 10.1109/10.1361
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1.
R. Brinkman, W. S. Cost, R. K. Koopmans and W. G. Zylstra, "Continuous observation on the percentage oxygen saturation of capillary blood in patients", Arch. Chir. Neerl., vol. 1, pp. 184-191, 1949.
2.
M. L. Polanyi and R. M. Hehir, "In vivo oximeter with fast dynamic response", Rev. Sci. Instrum., vol. 33, no. 10, pp. 1050-1054, 1962.
3.
C. C. Johnson, R. D. Palm and D. C. Stewart, "A solid state fiber-optics oximeter", J. Ass. Advan. Med. Instrum., vol. 5, pp. 77-83, 1972.
4.
S. Yee, E. Schibli and V. Krishnan, "A proposed miniature red/ infrared oximeter suitable for mounting on a catheter tip", IEEE Trans. Biomed. Eng., vol. BME-24, pp. 195-197, Feb. 1977.
5.
J. M. Schmitt, J. D. Meindl and R. G. Mihm, "An integrated circuit-based optical sensor for in vivo measurement of blood oxygenation", IEEE Trans. Biomed. Eng., vol. BME-33, pp. 98-107, Feb. 1986.
6.
G. G. Vurek, T. Kolobow, S. E. Pegram and W. S. Friauf, "Oxygen saturation monitor for extra-coiporeal circulation applications", Med. Instrum., vol. 7, no. 4, pp. 262-267, 1973.
7.
A. Cohen and N. Wadsworth, "A light emitting diode skin reflection oximeter", Med. Biol. Eng., vol. 10, pp. 385-391, 1972.
8.
S. Takatani, P. W. Cheung and E. A. Ernst, "Noninvasive tissue reflectance oximeter: An instrument for measurement of tissue hemoglobin oxygen saturation in vivo", Ann. Biomed. Eng., vol. 8, pp. 1-15, 1980.
9.
Y. Mendelson, P. W. Cheung, M. R. Neuman, D. G. Fleming and S. D. Cahn, "Spectrophotometry investigation of pulsatile blood flow for transcutaneous reflectance oximetry", Oxygen Transport Tissue, vol. 4, pp. 93-102, 1983.
10.
C. Scoggin, L. Nett and T. L. Petty, "Clinical evaluation of a new ear oximeter", Heart and Lung, vol. 6, no. 1, pp. 121-126, 1977.
11.
T. Yoshiya, Y. Shimada and K. Tanaka, "Spectrophotometry monitoring of arterial oxygen saturation in the fingertip", Med. Biol. Eng., vol. 18, pp. 27-32, 1980.
12.
O. M. D. Siggaard-Anderson, "Experiences with a new direct reading oxygen saturation photometer using ultrasound for hemolyzing the blood", Scand. J. Clin. Lab. Invest., vol. AS-59, 1977.
13.
A. Zwart, A. Buusma, B. Oeseburg and W. G. Zijlstra, "Determination of hemoglobin derivatives with the IL 282 CO-oximeter as compared with a manual spectrophotometric five-wavelength method", Clin. Chem., vol. 27, no. 11, pp. 1903-1907, 1981.
14.
R. N. Pittman and B. R. Duling, "A new method for the measurement of percent oxyhemoglobin", J. Appl. Physiol., vol. 38, no. 2, pp. 315-320, 1975.
15.
D. W. Lubbers, "Spectrophotometric examination of tissue oxygenation", O Transport Tissue, pp. 45-54, 1975.
16.
T. E. J. Gayeski, J. Hoffmann, H. Grisar and D. W. Lubbers, "The calculation of hemoglobin saturation in single erythrocytes", Oxygen Transport Tissue, vol. VII, pp. 899-908, 1984.
17.
P. L. Baele, J. C. McMihan and H. M. March, "Continuous monitoring of mixed venous oxygen saturation in critically-ill patients", Anesth. Analg., vol. 6, pp. 513, 1982.
18.
V. Twersky, "Absorption and multiple scattering by biological suspensions", J. Opt. Soc. Amer., vol. 60, no. 8, pp. 1084-1093, 1970.
19.
P. Kubelka and F. Munk, "Ein Beitrang zur Optik der Farbanstriche", Z. techn. Phys., vol. 12, pp. 593-601, 1931.
20.
P. W. Cheung, Effects of blood physiological variations on optical scattering and fiberoptic oximetry, 1973.
21.
R. L. Longini and R. Zdrojkowski, "A note on the theory of back-scattering of light by living tissue", IEEE Trans. Biomed. Eng., vol. BME-15, pp. 4-10, 1968.
22.
L. O. Reynolds, Three dimensional reflection and transmission equations for optical diffusion in blood, 1970.
23.
A. Cohen and R. L. Longini, "Theoretical determination of the bloods relative oxygen saturation in vivo", Med. Biol. Eng., vol. 9, pp. 61-69, 1971.
24.
L. O. Reynolds, C. C. Johnson and A. Ishimaru, "Diffuse reflectance from a finite blood medium: Applications to the modeling of fiber optic catheters", Appl. Opt., vol. 15, pp. 2059-2067, 1976.
25.
C. C. Johnson, "Optical diffusion in blood", IEEE Trans. Biomed. Eng., vol. BME-17, pp. 129-133, 1970.
26.
S. Takatani and M. D. Graham, "Theoretical analysis of diffuse reflectance from a two layer tissue model", IEEE Trans. Biomed. Eng., vol. BME-26, no. 12, pp. 656-664, 1979.
27.
A. Ishimaru, "Theory and application of wave propagation and scattering in random media", Proc. IEEE, vol. 65, no. 7, pp. 1030-1061, 1977.
28.
S. Takatani, On the theory and development of a noninvasive tissue reflectance oximeter, 1978.
29.
J. M. Schmitt, F. G. Mihm and J. D. Meindl, "New methods for whole blood oximetry", Ann. Biomed. Eng., vol. 14, pp. 35-52, 1986.
30.
S. Takatani, P. W. Cheung and W. H. Ko, "Estimation of hemoglobin concentration of whole blood from infrared reflectance", ACEMB, vol. 18, pp. 348, 1976.
