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Alexandru Moldovan - IEEE Xplore Author Profile

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Non-destructive testing (NDT) using ultrasound (US) is crucial for inspecting nuclear power plant components, including the reactor pressure vessel. Current implementations result in a high cable count system with complex extended routing, which necessitates the development of highly integrated solutions. A novel high-voltage (HV) pulser application-specific integrated circuit (ASIC) was designed,...Show More
Ultrasound capsule endoscopy (USCE) promises to combine the usefulness of the traditional endoscope with the increased comfort, reduced risks, and wider reach of a capsule for diagnosis of gastrointestinal tract (GIT) diseases. Equipped with a microultrasound (µUS) array operating at frequencies higher than 20 MHz, the USCE device can benefit from increased axial resolution, while the use of an ar...Show More
Minaturised, cylindrical ultrasound arrays are showing great promise for applications such as intra-vasculature imaging for peripheral arterial disease, and borescope imaging of internal small pipework for defects or corrosion. However, manufacturing small-scale, high-frequency ultrasound arrays is typically challenging, costly, and time-consuming. Due to being constructed from bulky ceramics, the...Show More
High-frequency ultrasound (HFUS) has been gaining traction to achieve high-resolution subsurface images of human tissue. Such capability could be used to locate lesions in the gastrointestinal tract (GIT), leading to early diagnosis of GIT disorders, which is directly correlated with a positive outcome of treatment. Hence, it is important to develop system components that aid HFUS development. Acc...Show More
Sonomyography refers to the measurement of muscle activity with an ultrasonic transducer. It is a candidate modality for applications in diagnosis of muscle conditions, rehabilitation engineering and prosthesis control as an alternative to electromyography. We propose a mechanically-flexible piezoelectric sonomyography transducer. Simulating different components of the transducer, using COMSOL Mul...Show More
Ultrasound (US) and cavitation agents such as microbubbles (MBs) have been demonstrated to decrease the barrier function of endothelial and epithelial layers. However, in vitro experiments that study this effect are often hindered by the inability to deliver buoyant contrast agents in proximity to cell monolayers in order to adequately control the decrease in barrier function whilst insonating a s...Show More
A fully integrated high-voltage pulser driver was developed in TSMC 180 nm BCD for biomedical ultrasound applications. The driver operated at a 20 V regulated supply and was tested with 1.5 MHz and 3.0 MHz therapeutic arrays and a 550 pF capacitive load. The pulser was found to have the longest rise time of 2.1 ns at the maximum capacitive load, and the input-output delay was observed to be 14 ns....Show More
Microultrasound (µUS) arrays with operating frequencies beyond 25 MHz are suitable for subsurface diagnosis, e.g., dermatology, ophthalmology, intravascular US, because they offer increased image resolution compared to conventional, lower frequency devices. Presently, arrays made with 1–3 piezocomposite active materials are becoming increasingly attractive over bulk piezoelectric materials due to ...Show More
Standard in vitro models to study intestinal drug absorption and delivery, including ultrasound (US)-mediated drug delivery, are grown from tumorous colon and rectum cells. However, the intestinal epithelium is a heterogeneous tissue and includes stem cells that differentiate into multiple cell types, including those responsible for absorption of nutrients, secretion of mucus, sensing of nutrients...Show More
Precise control of ultrasonic (US) power is required during sonoporation to ensure pressure amplitude in the target tissue is maintained within the bounds of therapeutic efficiency and below the maximum threshold of safe use. Pressure mapping with a scanning tank and needle hydrophone (NH) represents a convenient means to evaluate US beam profiles and peak negative pressures (PNP) achieved by ther...Show More
Therapeutic efficiency of sonoporation is hampered by ultrasound attenuation, low focusing efficiency due to beam scattering from the variety of tissues in the propagation path, and heating. This paper describes the manufacturing and characterization of miniature 1-3 connectivity 1-D linear phased arrays of the size of an 8 Fr catheter for intracorporeal sonoporation. Their advantage over external...Show More
A 32-element, 5MHz linear array, incorporating PMN-PT 1-3 piezo-polymer composite, has been designed using finite element (FE) modelling. The Elasto-Electric material properties of the PMN-PT samples were characterized and evaluated within the FE model to ensure accurate corroboration. The array configuration and performance were then investigated, including array microstructure, and steering and ...Show More