Showing 1-25 of 71 resultsfor "Index Terms":Large Biomolecules
"Index Terms":Large Biomolecules
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Delivery of Large Cargo in Mammalian Cells Enhanced By Infrared Light Pulse-Activated Micro-Ring Device
Ashwini Shinde;Pallavi Shinde;Moeto Nagai;Tuhin Subhra Santra;Srabani Kar
2024 IEEE 19th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)
Year: 2024 | Conference Paper |
Cited by: Papers (1)
Achieving efficient and uniform intracellular delivery of biomolecules is vital in biological research, with broad implications for biomedicine. Here, we demonstrate a method using a titanium micro-ring (TMR) device activated by infrared (IR) light pulses for such delivery across diverse cell types. The TMR device, designed with micro-rings, generates photothermal cavitation bubbles upon IR laser ...Show More
Simulating electrical properties of interdigitated electrode designs for impedance-based biosensing applications
Scott MacKay;Peter Hermansen;David Wishart;Wayne Hiebert;Jie Chen
2015 IEEE 28th Canadian Conference on Electrical and Computer Engineering (CCECE)
Year: 2015 | Conference Paper |
Cited by: Papers (3)
In this paper, we describe a point-of-care biosensor design. The uniqueness of our design is in its capability for detecting a wide variety of target biomolecules and the simplicity of nanoparticle enhanced electrical detection. The electrical properties of interdigitated electrodes and the mechanism for gold nanoparticle-enhanced impedance-based biosensor systems based on these electrodes were si...Show More
Microfluidic systems using localized molecular imprinting polymers for detection of nano-scale bio-molecules based on surface plasmon resonance
Gwo-Bin Lee;Shean-Jen Chen;Shih-Chiang Huang;Fan-Ching Chien;Wen-Janq Chen
5th IEEE Conference on Nanotechnology, 2005.
Year: 2005 | Conference Paper |
This paper reports a new microfluidic system integrated with localized molecular imprinting polymers (MIP) for detection of nano-scale bio-molecules based on surface plasmon resonance (SPR). The label-free bio-sensing method incorporates SPR biosensing and an innovative microfluidic biochip capable of transporting a specific amount of bio-samples inside multiple microchannels using micropumps to s...Show More
The basic concept of interconnection-free biomolecular computing and its realization in a computing model based on the massive, natural parallelism between enzymes and their substrates are described. An approach to implementing the model is presented. The approach involves two primitive switching functions: detecting specific substrates in solution using enzyme-based biosensors and producing speci...Show More
Design and optimization of a CMOS front-end for magnetoresistive sensor based biomolecular recognition detection
Tiago Costa;Jose Germano;Moises S. Piedade;Filipe A. Cardoso;Paulo P. Freitas
2016 IEEE International Symposium on Circuits and Systems (ISCAS)
Year: 2016 | Conference Paper |
Cited by: Papers (1)
This paper reports a monolithic device integrating a CMOS analog front-end and an array of 192 MR sensors for biomolecular recognition detection. Innovative CMOS building blocks (i.e. current source, multiplexers and pre-amplifier) were designed targeting a negligible noise when compared with the MR sensors noise and a low power consumption. The CMOS front-end was fabricated using AMS 0.35 μm tech...Show More
Surface modification of silicananoparticles for immobilize probe DNA to identify aspergillus flavus
International Conference on Advanced Nanomaterials & Emerging Engineering Technologies
Year: 2013 | Conference Paper |
Cited by: Papers (1)
Nanomaterials such as silica nanoparticles works as sensor when probe hybridized with the target sequence. Due to their large surface area to volume ratio, they can achieve rapid and low cost reactions. They can conjugate with a variety of biomolecules (Proteins, enzymes, peptides, and DNA) and used as fluorescence biomarkers to monitor biological events or identify and detect biological targets. ...Show More
Functionalization of micro-Hall effect sensors for biomedical applications utilizing superparamagnetic beads
A. Lapicki;H. Sanbonsugi;T. Yamamura;N. Matsushita;M. Abe;H. Narimatsu;H. Handa;A. Sandhu
2005 IEEE International Magnetics Conference (INTERMAG)
Year: 2005 | Conference Paper |
This paper aims to meet demands of affordable and reliable analytical tools for detection, identification and quantification of DNA and other biomolecules. This work has two main objectives: (i) fabrication of Hall sensors that are compatible, with biological environment via a waterproof sensor passivation layer, insulation of electrical contacts, providing an interface for biomolecules, and suita...Show More
Theoretical triangular quantum well model for AlGaN/GaN HEMT structure used as polar liquid sensor
2012 10th IEEE International Conference on Semiconductor Electronics (ICSE)
Year: 2012 | Conference Paper |
Cited by: Papers (2)
A triangular quantum well model is introduced to investigate a doped AlGaN/GaN high electron mobility transistor (HEMT) structure as a sensor for polar liquids. We calculate the drain current of the transistor as a function of the dipole moment of the polar liquid. The results show good agreement with experimental measurements for different polar liquids. It is also found that the device has large...Show More
Polymer microring resonators for biochemical sensing applications
Polymer microring resonators were demonstrated for sensing biomolecules without using fluorescent labels. The microring devices, fabricated by a direct imprinting technique, possess high Q factors of /spl sim/20000. This feature provides high sensitivity and a low detection limit for biochemical sensing applications. With these properties, the devices were used to detect and quantify the biomolecu...Show More
Optimization of CMOS-ISFET-Based Biomolecular Sensing: Analysis and Demonstration in DNA Detection
Ion-sensitive field-effect transistors (ISFETs) have been used to detect a variety of biomolecules whose charges alter the current or threshold voltage of the transistor. ISFETs can be built into large-scale arrays by CMOS compatible technology, offering the promise of highly parallel, all-electrical biomolecule sensing in a true chip-scale construct. Although CMOS-ISFET-based biomolecule detectio...Show More
Terahertz Dielectric Sensitivity to Biomolecular Structure and Function
A review of recent terahertz (THz) dielectric response measurements on large biomolecules is presented. The origin of the dielectric response in this frequency range is discussed. We specifically address the questions of the relative contributions of collective vibrational modes and relaxational contributions. When sample uniformity is controlled and multiple reflection effects included in the ana...Show More
Development of plasmonics-active SERS substrates on a wafer scale for chemical and biological sensing applications
Anuj Dhawan;Yan Du;Hsinneng Wang;Donovon Leonard;Veena Misra;Mehmet Ozturk;Michael Gerhold;Tuan Vo-Dinh
2008 IEEE International Electron Devices Meeting
Year: 2008 | Conference Paper |
Cited by: Papers (3)
This paper describes the fabrication of highly efficient plasmonics-active SERS substrates - having metallic nanowire structures with pointed geometries and sub-5 nm gap between the metallic nanowires enabling concentration of high EM fields in these regions - on a wafer-scale by a reproducible process that is compatible with large-scale development of these substrates. These SERS substrates were ...Show More
Microfluidic Circulating Tumour Cell Sorter Using Deterministic Lateral Displacement
2021 IEEE International Conference on Distributed Computing, VLSI, Electrical Circuits and Robotics (DISCOVER)
Year: 2021 | Conference Paper |
Cited by: Papers (1)
This paper presents the separation of rare circulating tumour cells (CTCs) in the range of $15-30\mu \text{m}$ by designing the novel microfluidic channel to prognose the level of cancer. Prognosing the level of CTCs in a patient's blood sample will greatly reduce the mortality rate. The developed microchannel structure utilizes the concept of deterministic lateral lateral displacement. Inclusion ...Show More
How can chip technology realize electronic sensing of viruses?
2021 International Symposium on VLSI Technology, Systems and Applications (VLSI-TSA)
Year: 2021 | Conference Paper |
Regrettably, COVID-19 taught us how significant the portable virus sensing technology is. Before it, the cost issues and different regulations in various countries have hindered the widespread use of the Point-of-Care Testing (POCT). Suppose we can electronically control it using Si nanotechnology, named e-POCT. Following the concept of IoT sensors, we can expect that a plenty of deployed e- POCTs...Show More
Collective structural vibrational modes of proteins lay in the terahertz frequency range. We discuss several measurements exploring picosecond dynamics in hen egg white lysozyme suggesting that terahertz time domain spectroscopy can provide unique insight to critical protein dynamics. We find a rapid increase in terahertz absorbance and index at both a critical hydration point and separately a cri...Show More
Demonstration of a Vertically Stacked Junctionless Forksheet as Dielectric Modulated Biosensor
Navneet Gandhi;Rajeewa Kumar Jaisawal;P. N. Kondekar;Ankit Dixit;Naveen Kumar;Vihar Georgiev;Navjeet Bagga
2024 28th International Symposium on VLSI Design and Test (VDAT)
Year: 2024 | Conference Paper |
In this paper, we demonstrated the performance metrics of a Junctionless vertically stacked Forksheet FET for biosensing applications. Through the use of well-calibrated TCAD models, the N-and P-side of a Forksheet FET is designed with a cavity region where the presence/absence of the biomolecule is sensed using a permittivity modulation approach. The label-free electrical detection of different b...Show More
High sensitivity of sensors based on two-dimensional photonic crystal
2011 Saudi International Electronics, Communications and Photonics Conference (SIECPC)
Year: 2011 | Conference Paper |
Cited by: Papers (5)
Photonic crystals (PCs) have achieved a lot of research significance due to their projected applications. Their use as sensors is enabled due to their well-defined physical properties such as reflectance/ transmittance, superior levels of sensitivity resulting in precise detection limits. In this paper, we propose an ultracompact RI (refractive index) sensor based on single line photonic crystal w...Show More
Silk stabilized graphene FET enzymatic glucose biosensor
2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII)
Year: 2013 | Conference Paper |
Cited by: Papers (3)
This paper describes a silk fibroin-encapsulated graphene field effect transistor (FET) enzymatic biosensor that utilizes silk protein as both device substrate and enzyme immobilization material. Glucose molecules are detected by the conductance change and the Dirac point shift of the graphene transistor as the glucose is oxidized by glucose oxidase that was immobilized in silk fibroin film on the...Show More
Enhanced electrochemical detection of cardiovascular biomarker proteins using biogenic nanoporous silica diatoms
Krishna Vattipalli;Kai-Chun Lin;B. L. Ramakrishna;Shalini Prasad
2011 11th IEEE International Conference on Nanotechnology
Year: 2011 | Conference Paper |
Cited by: Papers (3)
The goal of our research is to demonstrate the feasibility of employing biogenic nanoporous silica as a key component in developing a biosensor platform for rapid label-free electrochemical detection of proteins from pure and commercial human serum samples with high sensitivity and selectivity. The biosensor platform consists of a silicon chip with an array of gold electrodes forming multiple sens...Show More
Molecular Communication as a Biological System
2018 IEEE International Conference on Sensing, Communication and Networking (SECON Workshops)
Year: 2018 | Conference Paper |
Cited by: Papers (3)
This paper presents a new view of molecular communication, molecular communication as a biological system. It is built upon fluctuations and interactions of molecules, i.e., building blocks of molecular communication. This paper discusses how fluctuations and interactions of molecules give rise to the small, large and critical numbers of molecules in biological systems. This paper also discusses r...Show More
Laser femtosecond MPI mass spectroscopy of dye-labeled nucleotides
S.V. Chekalin;V.V. Golovlev;Y.A. Matveets;A.P. Yartsev;V.S. Letokhov;C. Seidel;J. Wolfrum;K.O. Greulich
The laser multiphoton photoionization (MPI) mass spectroscopy technique was used to investigate the processes of photoionization and fragmentation of the nucleotides chemically bound to the label chromophore group. The results of experiments with nucleotide-coumarin complexes are presented. The experiments involved four nucleic acid bases-adenosine, cytosine, guanine, and thymine-bound to the coum...Show More
There is a need for accurate knowledge of complex permittivity of biosystems for development of electromagnetic diagnostic and therapeutic methods. However, standard open-ended coaxial probe method for measurement of complex permittivity requires rather large sample volumes which is prohibitive for analysis of many types precious biomolecules available only in small volumes. To help to alleviate t...Show More
Modeling of electron transport in biomolecules: Application to DNA
2013 IEEE International Electron Devices Meeting
Year: 2013 | Conference Paper |
Cited by: Papers (3)
We review our work aimed at understanding electron transport in DNA molecules and present new results on specific strands. The motivation for our work stems from both: (i) DNA offering a unique framework for nanoscale electronic devices and (ii) recent work to detect diseases by measuring electrical current in DNA. Designer sequences of DNA show the theoretical possibility to behave as superlattic...Show More
Nano-Honeycomb Electrode-Based QCM Sensor and Its Application for PPI Detection
Naoto Asai;Naohiro Matsumoto;Nozomi Kazama;Yasuo Nagaoka;Takaaki Sumiyoshi;Tomohiro Shimizu;Shoso Shingubara;Takeshi Ito
An anodic aluminon oxide-based nano-honeycomb electrode was fabricated on a quartz crystal to increase the surface area binding with an analyte for using as a sensing device in a quartz crystal microbalance to monitor the protein–protein interactions (PPIs). As examples, we detected PPIs of anti-Bcl-2 and Bcl-2, and Bcl-2 and Bax in real time. A sensor with a flat Au electrode showed a tiny freque...Show More
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