Phase-Resolved optical Doppler tomography (ODT) has very high sensitivity while maintaining a fast axial scanning rate, making it possible to reconstruct blood flow in three dimensions. Here, we demonstrate an ODT system that employed novel signal-processing techniques to remove aliasing effects and artifacts caused by lateral scanning and target movement. The results show that these techniques not only simplified ODT, but also improved lateral scanning speed. Using these signal-processing techniques, three-dimensional (3-D) images of in vivo blood vessels in human skin were then reconstructed ODT [1] [2] [3] has emerged as an extension of optical coherence tomography (OCT) [4] for performing high-resolution cross-sectional imaging of tissue structure and blood flow in vivo and in situ. A recently developed phase-resolved approach to ODT [5] further improved the sensitivity of detectable blood flow velocity (10 m/s) while maintaining high spatial resolution (10 m). Phase-resolved ODT [6] has been shown a very good methodology to study the microcirculation of human skin. However, in order to determine capillary structure, 3-D imaging is necessary to obtain vessel topology. In this paper, we describe two techniques to overcome the problems encountered when reconstructing vessels in three dimensions using phase-resolved ODT. We demonstrate the first 3-D images of in vivo blood vessels in human skin using phase-resolved ODT.
Abstract:
Phase-resolved optical Doppler tomography (ODT) has very high sensitivity while maintaining a fast axial scanning rate, making it possible to reconstruct blood flow in th...Show MoreMetadata
Abstract:
Phase-resolved optical Doppler tomography (ODT) has very high sensitivity while maintaining a fast axial scanning rate, making it possible to reconstruct blood flow in three dimensions. Here we demonstrate an ODT system that employed novel signal-processing techniques to remove aliasing effects and artifacts caused by lateral scanning and target movement. The results show that these techniques not only simplified ODT, but also improved lateral scanning speed. Using these signal-processing techniques, three-dimensional images of in vivo blood vessels in human skin were then reconstructed.
Published in: IEEE Journal of Selected Topics in Quantum Electronics ( Volume: 7, Issue: 6, Nov.-Dec. 2001)
DOI: 10.1109/2944.983296