I. Introduction
Gliomas represent the brain tumors that having the highest prevalence and mortality rate [1]. They represent about 80% of malignant brain tumors [2]. They can be grouped into Low Grade Gliomas (LGG) and High Grade Gliomas (HGG), where the HGG is more aggressive and infiltrative. On average, the patients cannot survive more than 14 months after diagnosis, even under treatment.