Microfluidic Circulating Tumour Cell Sorter Using Deterministic Lateral Displacement

This paper presents the separation of rare circulating tumour cells (CTCs) in the range of $15-30\mu \text{m}$ by designing the novel microfluidic channel to prognose the level of cancer. Prognosing the level of CTCs in a patient's blood sample will greatly reduce the mortality rate. The developed microchannel structure utilizes the concept of deterministic lateral lateral displacement. Inclusion of arrays of triangular posts with critical diameter of $42\mu \text{m}$ improves the separation efficiency. The optimistic microchannel’s efficiency is analyzed by validating critical diameter. Further particle tracing is employed and improved the device throughput.

I. Introduction

Nowadays, the mortality rate of human beings have been increases due to cancer. Cancer is the growth of a host cell without control and the host cell growth will produce several diseases to human organs. As a result the person succumbs to it. In the United States, the fatal rate attributed to cancer is one for every four deaths. It can be reduced only if it is precisely prognosed. During the previous decades, many researchers and health care professionals have shown garnering attention to make precise and low cost devices to prognose the count of CTCs from individual patients. As a result, it helps to identify or understand the metastatic process level and development of cancer [1].