I. Introduction
In order to isolate the medicine from the outside air and further to ensure the asepsis of the medicine in glass vials, glass vials vacuuming or nitrogen filling is usually used in the packaging process before glass vials flow into the market. Unfortunately, the package integrity of glass vials would be damaged inevitably due to the unstable plugs, the degeneration of packaging materials or even the man-made mis-operation. Therefore, the package integrity test [1] plays a crucial role in ensuring the sterility of the glass vials by measuring the oxygen concentration to verify the degree of gas exchange occurring inside and outside the glass medicine vials.