I. Introduction
The craniotomy is an essential neurosurgical process for removing a part of the patient's skull and is a safe and valid method to manage patients with brain tumors or chronic subdural hematoma [1]. Through image-guided surgery, surgeons could localize the lesion precisely. After that, they could accurately determine the optimal trajectory [2], and the target points as well as drilling points of craniotomy. By this procedure, the surgical tool can access a specific intracranial area under medical image guidance. In most cases of craniotomies, the surgeon should use a surgical tool to drill burr holes on the skull [3] which is time-consuming, dangerous, and laborious. During this procedure, the surgeon should hold the heavy (around 1 kg) drilling instrument with vibration and maintain a precise positioning control to avoid accidents. In this way of drilling, the surgeon's strength and concentration are drastically consumed. To finish the craniotomy and the follow-up operation (such as brain tumor removal), two experienced surgeons are required. Alternatively, with the help of the robot, one surgeon can conduct a whole craniotomy and the follow-up operation.