I. Introduction
The concept of Digital Twin (DT) is creating and maintaining a digital representation of the real physical entity and supporting its performance through simulation and optimization tools, which are fed with real and updated data. DT is a part of the digitalization and simulation pillar of Industry 4.0 paradigm [1]. The application of Industry 4.0 technologies in many sectors has been barely examined yet since the variation of sub-processes and manufacturing technologies results in a large number of potential combinations. DT technology may present a valuable tool for the rapid integration of Industry 4.0 in today's technologies. DT covers three components: knowledge content, effect, and functionality, and application domain [2]; for utilization of a DT technology, the relations of the three components must be recognized, and the gaps remaining for exploration identified.