I. Introduction
Optical sensing with visible light is used broadly across scientific applications, where its utility as a non-invasive measurement technique is essential for medical, environmental, and life sciences applications. In particular, low-noise imaging and fluorescence measurement rely heavily on high quality solid-state imagers, including cooled CCD sensors or scientific CMOS image sensors (CIS). For low-light, low-magnitude photocurrent sensing with CMOS image sensors, the integration time must be long, yielding low (<5 Hz) frame rates [1], and precise analog circuits are necessary to reduce temporal readout noise and signal-dependent junction leakage current.