I. Introduction
Clinical depression, unlike mood fluctuation, is a common mental disorder that lasts longer and causes disability and reduced functionality. A recent World Health Organization (WHO, 2012) survey estimated that 350 million people worldwide are affected by depression. With increased severity level, it might lead to suicide. Moreover, it causes more than two-thirds of suicides each year [1]. The suicide risk is more than 30 times higher among depressed patients than that of the population without these disorders [2]. Although treatment of depression disorders has proven to be effective in most cases [3], misdiagnosing depressed patients is a common barrier [4]. Moreover, the assessment methods of diagnosing depression rely almost exclusively on patient-reported or clinical judgments of symptom severity [5], risking a range of subjective biases. Based on the WHO, the barriers to effective diagnosis of depression include a lack of resources and trained health care providers. Our goal here is to investigate the general characteristics of depression, which we hope will lead to an objective affective sensing system that assists clinicians in their diagnosis and monitoring of clinical depression. Ultimately, we hope to assist patients with depression to monitor the progress of their illness.