I. Introduction
IN THE PAST two decades, computer-assisted surgery systems were introduced into the operation room [1], especially in neuro-, trauma and orthopedic surgery (cf. Fig. 1). Driving motivations for the introduction of IGS systems are
reduction of invasiveness, e.g., by optimizing the access route, minimizing ionizing radiation and reducing the unnecessary damages to neighboring tissues,
increase of safety and reliability of therapy e.g. by improving intervention accuracy, visualizing critical organs and detections of human errors as early as possible in the surgical process,
introduction of novel interventions, e.g., by definition of new noninvasive interventions which are only possible under precise navigation and multi-modal imaging.