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A Head Phantom Study of Frontal Lobe Epilepsy Localization With Multichannel Acoustoelectric Brain Imaging | IEEE Journals & Magazine | IEEE Xplore
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Journals & Magazines >IEEE Sensors Journal >Volume: 24 Issue: 19

A Head Phantom Study of Frontal Lobe Epilepsy Localization With Multichannel Acoustoelectric Brain Imaging

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Gangnan Han; Xizi Song; Xinrui Chen; Tong Han; Minpeng Xu; Dong Ming
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Abstract:

Acoustoelectric brain imaging (ABI) is a new modality for mapping brain electrical activity. This study demonstrates the feasibility of multichannel ABI for frontal lobe ...Show More

Metadata

Abstract:

Acoustoelectric brain imaging (ABI) is a new modality for mapping brain electrical activity. This study demonstrates the feasibility of multichannel ABI for frontal lobe epilepsy localization with millimeter spatial resolution. First, the feasibility of frontal signal detection of ABI is investigated with different electrode configurations in both simulation and head phantom experiments. Both single-channel and multichannel ABI are considered, and the simulated electroencephalography (EEG) is also conducted for comparison. Besides, with multichannel ABI, the performance of frontal lobe epilepsy location is investigated. With head phantom experiment, three kinds of frontal lobe seizures are discussed, including focal onset, focal to bilateral tonic-clonic, and bilateral onset. The average offsets of EEG map and single-channel ABI are 17 and 2.8 mm, respectively, and spatial resolutions are 15.6 and 5.8 mm, respectively. Consistent with simulation results, the spatial resolution of single-channel ABI is 2.3 mm and the SNR is 14.3 dB. Besides, compared to that of single-channel ABI, the correlation coefficient (CC) of multichannel ABI is improved by 10%. In the Y plane, the offset of multichannel ABI is 1.3 mm, which is improved by 58% compared with single-channel ABI. What is more, the frontal lobe epilepsy can be accurately located by multichannel ABI with the offset less than 2 mm, and the time-frequency features of frontal lobe seizure can be distinguished in hertz level. Both simulation and phantom experiments validate that multichannel ABI can identify and locate different seizure types in both time and spatial domain within millimeter level. It is potential to bring new opportunities for noninvasive and high spatiotemporal resolution epilepsy monitoring.
Published in: IEEE Sensors Journal ( Volume: 24, Issue: 19, 01 October 2024)
Page(s): 30244 - 30253
Date of Publication: 28 August 2024

ISSN Information:

DOI: 10.1109/JSEN.2024.3447912

Funding Agency:

Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin, China
Gangnan Han received the B.S. degree from Tianjin University (TJU), Tianjin, China, in 2019. He is currently pursuing the Ph.D. degree in biomedical engineering with the Academy of Medical Engineering and Translation Medicine, TJU.
His main research interest is acoustoelectric brain imaging.
Gangnan Han received the B.S. degree from Tianjin University (TJU), Tianjin, China, in 2019. He is currently pursuing the Ph.D. degree in biomedical engineering with the Academy of Medical Engineering and Translation Medicine, TJU.
His main research interest is acoustoelectric brain imaging.View more
Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin, China
Xizi Song (Member, IEEE) received the B.S. degree in electronic information engineering from Hebei Normal University, Shijiazhuang, Hebei, China, in 2012, and the Ph.D. degree in control science and engineering from Tianjin University (TJU), Tianjin, China, in 2018.
In 2017, she joined the Experimental Ultrasound and Neural Imaging Laboratory, University of Arizona, Tucson, AZ, USA, as a Visiting Student. She is currently ...Show More
Xizi Song (Member, IEEE) received the B.S. degree in electronic information engineering from Hebei Normal University, Shijiazhuang, Hebei, China, in 2012, and the Ph.D. degree in control science and engineering from Tianjin University (TJU), Tianjin, China, in 2018.
In 2017, she joined the Experimental Ultrasound and Neural Imaging Laboratory, University of Arizona, Tucson, AZ, USA, as a Visiting Student. She is currently ...View more
Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin, China
Xinrui Chen received the B.S. degree in biomedical engineering from Jiangsu University, Jiangsu, China, in 2018. She is currently pursuing the Ph.D. degree in biomedical engineering with Tianjin University (TJU), Tianjin, China.
Her major research interest is acoustoelectric brain imaging.
Xinrui Chen received the B.S. degree in biomedical engineering from Jiangsu University, Jiangsu, China, in 2018. She is currently pursuing the Ph.D. degree in biomedical engineering with Tianjin University (TJU), Tianjin, China.
Her major research interest is acoustoelectric brain imaging.View more
Department of Radiology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin University, Tianjin, China
Tong Han (Member, IEEE) received the Ph.D. degree from Tianjin Medical University, Tianjin, China, in 2011.
He is with the Department of Radiology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin University (TJU), Tianjin. His research interests are basic and clinical research on structural and functional imaging of nervous system diseases.
Tong Han (Member, IEEE) received the Ph.D. degree from Tianjin Medical University, Tianjin, China, in 2011.
He is with the Department of Radiology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin University (TJU), Tianjin. His research interests are basic and clinical research on structural and functional imaging of nervous system diseases.View more
Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin, China
Minpeng Xu (Senior Member, IEEE) received the B.S. and Ph.D. degrees in biomedical from Tianjin University (TJU), Tianjin, China, in 2010 and 2015, respectively.
He visited Tzyy-Ping Jung’s Laboratory, Institute for Neural Computation (INC), University of California at San Diego (UCSD), San Diego, CA, USA, from 2014 to 2015. Since 2015, he has successively been a Lecturer, an Assistant Professor, and an Associate Professor...Show More
Minpeng Xu (Senior Member, IEEE) received the B.S. and Ph.D. degrees in biomedical from Tianjin University (TJU), Tianjin, China, in 2010 and 2015, respectively.
He visited Tzyy-Ping Jung’s Laboratory, Institute for Neural Computation (INC), University of California at San Diego (UCSD), San Diego, CA, USA, from 2014 to 2015. Since 2015, he has successively been a Lecturer, an Assistant Professor, and an Associate Professor...View more
Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin, China
Dong Ming (Senior Member, IEEE) received the B.S. and Ph.D. degrees in biomedical engineering from Tianjin University (TJU), Tianjin, China, in 1999 and 2004, respectively.
From 2002 to 2003, he was a Research Associate with the Department of Orthopedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. From 2005 to 2006, he was a Visiting Scholar with the Division of Mechanical Eng...Show More
Dong Ming (Senior Member, IEEE) received the B.S. and Ph.D. degrees in biomedical engineering from Tianjin University (TJU), Tianjin, China, in 1999 and 2004, respectively.
From 2002 to 2003, he was a Research Associate with the Department of Orthopedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. From 2005 to 2006, he was a Visiting Scholar with the Division of Mechanical Eng...View more
Contents

I. Introduction

Epilepsy is a clinical syndrome caused by highly abnormal discharge of brain neurons, which is characterized by transience, repeatability, and inflexibility. Complex distribution and diffusion range of abnormal discharge leads to different seizure patterns, which acts as sensory, motor, conscious, mental, behavioral disfunction, and other different functional disorders in clinical [1], [2]. Therefore, epilepsy is a great health hazard to human beings in both physical and mental aspects.

Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin, China
Gangnan Han received the B.S. degree from Tianjin University (TJU), Tianjin, China, in 2019. He is currently pursuing the Ph.D. degree in biomedical engineering with the Academy of Medical Engineering and Translation Medicine, TJU.
His main research interest is acoustoelectric brain imaging.
Gangnan Han received the B.S. degree from Tianjin University (TJU), Tianjin, China, in 2019. He is currently pursuing the Ph.D. degree in biomedical engineering with the Academy of Medical Engineering and Translation Medicine, TJU.
His main research interest is acoustoelectric brain imaging.View more
Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin, China
Xizi Song (Member, IEEE) received the B.S. degree in electronic information engineering from Hebei Normal University, Shijiazhuang, Hebei, China, in 2012, and the Ph.D. degree in control science and engineering from Tianjin University (TJU), Tianjin, China, in 2018.
In 2017, she joined the Experimental Ultrasound and Neural Imaging Laboratory, University of Arizona, Tucson, AZ, USA, as a Visiting Student. She is currently an Associate Professor with the Academy of Medical Engineering and Translation Medicine, TJU. Her current research interests include acoustoelectric brain imaging, neuroimaging, and neuromodulation.
Xizi Song (Member, IEEE) received the B.S. degree in electronic information engineering from Hebei Normal University, Shijiazhuang, Hebei, China, in 2012, and the Ph.D. degree in control science and engineering from Tianjin University (TJU), Tianjin, China, in 2018.
In 2017, she joined the Experimental Ultrasound and Neural Imaging Laboratory, University of Arizona, Tucson, AZ, USA, as a Visiting Student. She is currently an Associate Professor with the Academy of Medical Engineering and Translation Medicine, TJU. Her current research interests include acoustoelectric brain imaging, neuroimaging, and neuromodulation.View more
Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin, China
Xinrui Chen received the B.S. degree in biomedical engineering from Jiangsu University, Jiangsu, China, in 2018. She is currently pursuing the Ph.D. degree in biomedical engineering with Tianjin University (TJU), Tianjin, China.
Her major research interest is acoustoelectric brain imaging.
Xinrui Chen received the B.S. degree in biomedical engineering from Jiangsu University, Jiangsu, China, in 2018. She is currently pursuing the Ph.D. degree in biomedical engineering with Tianjin University (TJU), Tianjin, China.
Her major research interest is acoustoelectric brain imaging.View more
Department of Radiology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin University, Tianjin, China
Tong Han (Member, IEEE) received the Ph.D. degree from Tianjin Medical University, Tianjin, China, in 2011.
He is with the Department of Radiology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin University (TJU), Tianjin. His research interests are basic and clinical research on structural and functional imaging of nervous system diseases.
Tong Han (Member, IEEE) received the Ph.D. degree from Tianjin Medical University, Tianjin, China, in 2011.
He is with the Department of Radiology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin University (TJU), Tianjin. His research interests are basic and clinical research on structural and functional imaging of nervous system diseases.View more
Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin, China
Minpeng Xu (Senior Member, IEEE) received the B.S. and Ph.D. degrees in biomedical from Tianjin University (TJU), Tianjin, China, in 2010 and 2015, respectively.
He visited Tzyy-Ping Jung’s Laboratory, Institute for Neural Computation (INC), University of California at San Diego (UCSD), San Diego, CA, USA, from 2014 to 2015. Since 2015, he has successively been a Lecturer, an Assistant Professor, and an Associate Professor with the Department of Biomedical Engineering, TJU. He is the author of more than 80 articles and more than 20 inventions. His research interests include brain-computer interface, neuromodualtion, and neuroimaging.
Minpeng Xu (Senior Member, IEEE) received the B.S. and Ph.D. degrees in biomedical from Tianjin University (TJU), Tianjin, China, in 2010 and 2015, respectively.
He visited Tzyy-Ping Jung’s Laboratory, Institute for Neural Computation (INC), University of California at San Diego (UCSD), San Diego, CA, USA, from 2014 to 2015. Since 2015, he has successively been a Lecturer, an Assistant Professor, and an Associate Professor with the Department of Biomedical Engineering, TJU. He is the author of more than 80 articles and more than 20 inventions. His research interests include brain-computer interface, neuromodualtion, and neuroimaging.View more
Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin, China
Dong Ming (Senior Member, IEEE) received the B.S. and Ph.D. degrees in biomedical engineering from Tianjin University (TJU), Tianjin, China, in 1999 and 2004, respectively.
From 2002 to 2003, he was a Research Associate with the Department of Orthopedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. From 2005 to 2006, he was a Visiting Scholar with the Division of Mechanical Engineering and Mechatronics, University of Dundee, Dundee, U.K. In 2006, he joined the College of Precision Instruments and Optoelectronics Engineering, TJU, Philadelphia, PA, USA,, as a Faculty Member, where he has been a Full Professor of Biomedical Engineering, since 2011. He is currently the Chair Professor of the Department of Biomedical Engineering and the Director of Tianjin Neural Engineering Center and the Academy of Medical Engineering and Translational Medicine, TJU. He has managed almost 20 national and international research projects. His current research interests include neural engineering, rehabilitation engineering, sports science, biomedical instrumentation, and signal/image processing, especially in brain-computer interface, functional electrical stimulation, and gait analysis.
Dr. Ming is the chair of the IEEE-EMBS Tianjin Chapter.
Dong Ming (Senior Member, IEEE) received the B.S. and Ph.D. degrees in biomedical engineering from Tianjin University (TJU), Tianjin, China, in 1999 and 2004, respectively.
From 2002 to 2003, he was a Research Associate with the Department of Orthopedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. From 2005 to 2006, he was a Visiting Scholar with the Division of Mechanical Engineering and Mechatronics, University of Dundee, Dundee, U.K. In 2006, he joined the College of Precision Instruments and Optoelectronics Engineering, TJU, Philadelphia, PA, USA,, as a Faculty Member, where he has been a Full Professor of Biomedical Engineering, since 2011. He is currently the Chair Professor of the Department of Biomedical Engineering and the Director of Tianjin Neural Engineering Center and the Academy of Medical Engineering and Translational Medicine, TJU. He has managed almost 20 national and international research projects. His current research interests include neural engineering, rehabilitation engineering, sports science, biomedical instrumentation, and signal/image processing, especially in brain-computer interface, functional electrical stimulation, and gait analysis.
Dr. Ming is the chair of the IEEE-EMBS Tianjin Chapter.View more
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