A One-Step Soft Lithography Technique for Making Microfluidic Pdms Chips with Macro-Scale Structures | IEEE Conference Publication | IEEE Xplore

A One-Step Soft Lithography Technique for Making Microfluidic Pdms Chips with Macro-Scale Structures


Abstract:

A one-step molding technique was developed to fabricate a PDMS chip containing both microstructures and macrostructures such as inlets, outlets and reservoirs. The most c...Show More

Abstract:

A one-step molding technique was developed to fabricate a PDMS chip containing both microstructures and macrostructures such as inlets, outlets and reservoirs. The most critical step for molding was to establish the connection between macroscale and microscale features, which was achieved by blocking the through hole of a rigid mold with an elastic cone. The elastic cones and macrostructures were fabricated on the elastic mold, while micro structures were fabricated on the rigid mold. As a result, a digital PCR chip with four sample throughputs has been successfully fabricated. This technique is expected to be used to fabricate a wide variety of microfluidic chips.
Date of Conference: 21-25 January 2024
Date Added to IEEE Xplore: 22 February 2024
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Conference Location: Austin, TX, USA

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INTRODUCTION

Microfluidic technology can accurately control the movement of tiny amounts of liquid in micrometer scale flow channels [1]. Due to its advantages of small sample volume, fast reaction speed, high detection sensitivity, low cost, and portability, microfluidic platform is widely used in biological detection [2], chemical analysis [3]. Microfluidic chip design and manufacturing has been a hot topic in the scientific research field and commercial market. At present, the common materials used to manufacture microfluidic devices mainly include Polymethyl methacrylate (PMMA), glass, silicon, Polydimethylsiloxane (PDMS) and so on [4]. Among them, PDMS has become the most commonly used raw material for microfluidic chips in conventional laboratories due to its excellent physical and chemical properties [5], [6].

References

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