Fragment assembly protein structure prediction is one of the most successful methods whenever reliable templates (for homology-based approaches) and/or massive computational resources (for physics-based approaches) are not available. However, it suffers from important limitations: tremendous search space, energy scores inaccuracy, and consequently the large number of decoys which are needed to be ...Show More
Protein structure prediction has been one of the most challenging tasks undertaken in bioinformatics. Fragment assembly methodologies have emerged as the most accurate approaches to predict protein conformations without the need of homologues. Rosetta - a fragment-based tool - has consistently been at the forefront for two decades. Rosetta assembles candidate conformations using fragments of lengt...Show More
Despite some limited success, computational biology has not been able to produce reliable results in the field of protein structure prediction. Although the fragment assembly approach has shown a lot of potential, it still requires substantial improvements. Not only are its predictions largely inaccurate whenever a protein exceeds 150 amino acids in length, but also, even for short targets, incons...Show More
Multitasking in both uniprocessor (multithreading) and multiprocessor (multiprocessing) systems have been attracted by many applications. Database systems are somewhat the most important in this regard, especially in centralized and humongous ones. Sometimes thousands, and maybe hundred of thousands of operations are sent to the transaction processing system per second. To handle this bottleneck s...Show More