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Lucas J. van Vliet - IEEE Xplore Author Profile

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Quantitative MRI methods that estimate multiple physical parameters simultaneously often require the fitting of a computational complex signal model defined through the Bloch equations. Repeated Bloch simulations can be avoided by matching the measured signal with a precomputed signal dictionary on a discrete parameter grid (i.e. lookup table) as used in MR Fingerprinting. However, accurate estima...Show More
The goal of this paper is to increase the statistical power of crossing-fiber statistics in voxelwise analyses of diffusion-weighted magnetic resonance imaging (DW-MRI) data. In the proposed framework, a fiber orientation atlas and a model complexity atlas were used to fit the ball-and-sticks model to diffusion-weighted images of subjects in a prospective population-based cohort study. Reproducibi...Show More
The morphometric parameters of the corneal endothelium - cell density (ECD), cell size variation (CV), and hexagonality (HEX) - provide clinically relevant information about the cornea. To estimate these parameters, the endothelium is commonly imaged with a non-contact specular microscope and cell segmentation is performed to these images. In previous work, we have developed several methods that, ...Show More
Corneal endothelium images obtained by in vivo specular microscopy provide important information to assess the health status of the cornea. Estimation of clinical parameters, such as cell density, polymegethism, and pleomorphism, requires accurate cell segmentation. State-of-the-art techniques to automatically segment the endothelium are error-prone when applied to images with low contrast and/or ...Show More
People with diabetes mellitus need annual screening to check for the development of diabetic retinopathy (DR). Tracking small retinal changes due to early diabetic retinopathy lesions in longitudinal fundus image sets is challenging due to intraand intervisit variability in illumination and image quality, the required high registration accuracy, and the subtle appearance of retinal lesions compare...Show More
Purpose: To increase the sensitivity in longitudinal analysis of DW-MRI data with the ball-and-sticks model. Methods: Longitudinal DW-MRI data (baseline and two follow-up scans) of 25 middle-aged subjects (47 to 61 years at base line) were acquired. After coregistering all the diffusion-weighted images (DWIs) from the baseline and follow-up scans to a subject-specific intermediate space, an extend...Show More
Extraction of image-based biomarkers, such as the presence, visibility, or thickness of a certain layer, from 3-D optical coherence tomography data provides relevant clinical information. We present a method to simultaneously determine the number of visible layers in the outer retina and segment them. The method is based on a model selection approach with special attention given to the balance bet...Show More
Accurate quantification of retinal structures in 3-D optical coherence tomography data of eyes with pathologies provides clinically relevant information. We present an approach to jointly segment retinal layers and lesions in eyes with topology-disrupting retinal diseases by a loosely coupled level set framework. In the new approach, lesions are modeled as an additional space-variant layer delinea...Show More
The attenuation coefficient (AC) is a tissue property that can be estimated from optical coherence tomography (OCT) data. We observed that excessive noise below the retina might cause both an underestimation and a significant variation of the estimated AC values by a state-of-the-art algorithm. Two methods were proposed to reduce these effects: I) by removing the average noise signal from the OCT ...Show More
We present a locally-adaptive approach to segment the fluid and the interfaces between retinal layers in eyes affected by central serous retinopathy based on loosely-coupled level sets. The approach exploits the local attenuation coefficient differences of layers around an interface and introduces auxiliary interfaces to delineate the fluid. Thus, it can handle abrupt attenuation coefficient varia...Show More
Registration of images in the presence of intra-image signal fluctuations is a challenging task. The definition of an appropriate objective function measuring the similarity between the images is crucial for accurate registration. This paper introduces an objective function that embeds local phase features derived from the monogenic signal in the modality independent neighborhood descriptor (MIND)...Show More
This paper presents a method to determine the number of visible layers in the outer retina and perform segmentation. Each layer in the outer retina is represented by a Gaussian function, and multiple models with a different number of layers are used to form the outer retina. Parameters of competing models are calculated by using maximum likelihood estimation after which the model that best describ...Show More
In diffusion-weighted magnetic resonance imaging (DW-MRI), the detection of microstructural change in brain white matter structures that border cerebrospinal fluid (CSF) is complicated by partial volume effects. The conventional diffusion tensor model is very sensitive to CSF contamination, which may leave subtle microstructural change undetected or may lead to detection of spurious microstructura...Show More
Diffusion-weighted MRI (DW-MRI) can assess the integrity of white matter (WM) structures in the human brain. Multi-compartment analysis of DW-MRI requires an estimate of the number of compartments to permit unbiased estimation of the diffusion shape in a single fibers as well as crossing fascicles. We propose a new, rotation-invariant measure to assess the suitability of a model by a measure for i...Show More
This paper studies a novel method to compensate for respiratory and peristaltic motions in abdominal dynamic contrast enhanced magnetic resonance imaging. The method consists of two steps: 1) expiration-phase “template” construction and retrospective gating of the data to the template; and 2) nonrigid registration of the gated volumes. Landmarks annotated by three experts were used to directly ass...Show More
This paper presents a novel method for the segmentation of layered structures that have a predefined order. Layers are jointly segmented by simultaneous detection of their interfaces. This is done by means of a level set approach based on Bayesian inference where the ordering of the layers is enforced via a novel level set coupling. The method was applied to in-vivo images of healthy human retinas...Show More
CT colonography (CTC) is one of the recommended methods for colorectal cancer screening. The subject's preparation is one of the most burdensome aspects of CTC with a cathartic bowel preparation. Tagging of the bowel content with an oral contrast medium facilitates CTC with limited bowel preparation. Unfortunately, such preparations adversely affect the 3-D image quality. Thus far, data acquired a...Show More
The grading of inflammatory bowel disease (IBD) severity is important to determine the proper treatment strategy and to quantify the response to treatment. Traditionally, ileocolonoscopy is considered the reference standard for assessment of IBD. However, the procedure is invasive and requires extensive bowel preparation. Magnetic resonance imaging (MRI) has become an important tool for determinin...Show More
In clinical practice, detection and quantification of calcified lesions in the coronary arteries and aorta is normally performed on non contrast enhanced Computed Tomography (CT) scans. This CT scan is generally followed by a contrast enhanced angiography (CTA) scan for better plaque visualization. We propose and evaluate a method for the detection of calcified lesions on CTA scans. Calcium lesion...Show More
Lumen segmentation is relevant for quantification of the degree of stenoses and as preprocessing step for the analysis of the vessel wall, and for the simulation and planing of interventions. Although lumen segmentation in CTA has received considerable interest, it remains a challenge for atherosclerotic vessels. In this paper we propose a semi-automatic lumen segmentation method using a levelset ...Show More
Direct imaging of ligament damage in the wrist remains a challenge. Still, such damage can be assessed indirectly through the analysis of changes in wrist pose and motion pattern. For this purpose we built a statistical reference model that describes healthy motion patterns. We show that such a model can also be used to detect and quantify pathologies. A model that only describes the global transl...Show More
Patient studies based on diffusion tensor images (DTI) require spatial correspondence between subjects. We propose to obtain the correspondence from white matter tracts, by introducing a new method for nonrigid matching of white matter fiber tracts in DTI. The method boils down to point set registration that involves simultaneously clustering and matching of the data points. The tracts are implici...Show More
Multiframe super-resolution (SR) reconstruction of small moving objects against a cluttered background is difficult for two reasons: a small object consists completely of “mixed” boundary pixels and the background contribution changes from frame-to-frame. We present a solution to this problem that greatly improves recognition of small moving objects under the assumption of a simple linear motion m...Show More
Diffusion Tensor MRI (DTI) is a rather recent image acquisition modality that can help identify disease processes in nerve bundles in the brain. Due to the large and complex nature of such data, its analysis requires new and sophisticated pipelines that are more efficiently executed within a grid environment. We present our progress over the past four years in the development and porting of the DT...Show More
A reliable density estimate for the position of the coronary arteries in Computed Tomography (CT) data is beneficial for many coronary image processing applications, such as vessel tracking, lumen segmentations, and calcium scoring. This paper presents a method for obtaining an estimate of the coronary artery location in CT and CT angiography (CTA). The proposed method constructs a patient-specifi...Show More