Positron Emission Tomography (PET)-based molecular imaging represents one of the most powerful tools to measure tumor biology variations and tumor microenvironment heterogeneity, which are major factors impacting cancer treatment failure. In this respect, Spatiotemporal Distribution Models based on Partial Differential Equations can provide an informative picture of in vivo cancer biology, ultimat...Show More
In dynamic brain positron emission tomography (PET) studies, acquiring a time series of images, typically lasting more than an hour, is necessary to derive pharmacokinetic parameters. Analytically, these parameters are estimated by establishing kinetic models such as compartment models that consist of sets of ordinary differential equations (ODEs), and by fitting the sparse time-activity curve (TA...Show More
