Tracking the Effects of Tumor Treating Fields on Human Breast Cancer Cells in vitro Using a Capacitance Sensing Lab-on-CMOS Microsystem

We report on a novel microsystem for assessing the effects of tumor treating fields on cancer cells. The platform features at its core an integrated capacitance sensor fabricated in a
$\mathbf{0.35} \mu \mathbf{m}$
CMOS process. The device also includes a cell culture well and miniaturized electrodes for generating arbitrary TTField spatial patterns. The measured capacitance data show a clear distinction between cell cultures treated with TTFields relative to those that remain unexposed. The proposed approach provides an inexpensive, real-time, and label-free means to conduct mechanistic TTField studies in vitro.