Role of Nitric Oxide and some Antioxidants in Women with Pregnancy-induced Hypertension

Pregnancy-induced hypertension is a primary factor to mother and fetal morbidity and mortality (PIH). Until now, the treatment has been symptomatic. Early detection and monitoring of illness development may help to avoid negative consequences. The study's goal was to determine the impact of nitric oxide and some antioxidants in women with high blood pressure caused by pregnancy. The study included 40 cases, 20 patients and 20 controls, and was conducted on a group of pregnant women with high blood pressure at Shatra General Hospital in Thi Qar Governorate between 5/10/2018 and 10/1/2019. About 40 blood samples were taken from pregnant women., and these samples were divided into two groups:: There were 20 pregnant women and 20 non-pregnant women in the study. The results were higher concentrations of MD A, Cp in patients compared to control, but in NO, V.E, V.C, the concentrations in patients were lower compared to control. There is a mismatch the relationship between antioxidant vitamin levels and nitric oxide production. High oxidative stress may be a cause of hypertension, however supplementing with vitamins C and E later in pregnancy, following placentation, may be “too little, too late” to avoid clinical trials manifestations of the predicament. We also can't rule out the possibility that an insufficient amount of vitamins C and E is having an impact, or that other antioxidants are more powerful. Antioxidants that target oxidative stress with a “wide brush” may be unsuitable during pregnancy.