Non-labeling Detection of Specific Intermolecular Bonding Using THz-SPR of Topological Insulator Bi2Se3

Terahertz (THz) wave length, corresponding to intermolecular binding energy, is the key to realize a non-labeling bio-medical sensor. We aim to enhance the sensitivity by a selective resonant excitation effect of the specific chemical binding and surface plasmon at the THz band. Here, we report the non-labeling detection of biomolecular binding by topological insulator THz-SPR. Bi
2
Se
3
was processed in a microribbon array to enhance SPR in THz range. The sugar chain-lectin specific binding, which has weaker interactions than antigen-antibody binding, was observed due to the enhancement of Bi
2
Se
3
THz-SPR.