Features of Neuron-Glial Networks Reorganiztion In Modeled Neurodegenerative Processes In Vitro

Features of neuron-glial networks reorganization in primary hippocampal cultures under chronic amyloid beta (Aβ) application have been studied. Primary hippocampal cultures were obtained from C57Bl/6 murine embryos and cultured during 21 days. The studies revealed the significant decrease in the key parameters characterizing connectivity of cells in a culture and simplification of functional neuron-glial networks.