Numerical Modeling of Glucose Biosensor With pH-Based Electrochemical Field-Effect Transistor Device

In this article, we present a new model for glucose detection using an electrochemical field-effect transistor (ElecFET) with the MATLAB software. ElecFET is a device in which the basic element is a pH-sensitive chemical field-effect transistor (pH-ChemFET) designed with an integrated platinum microelectrode around the sensitive gate dielectric capable to trigger electrochemical reactions. A number of parameters, such as polarization time (T
_pol
) and polarization voltage (V
_p
), have been investigated, as well as the enzymatic unit number per volume (N
_enz
), the Michaelis constant (K
_M
), and the glucose concentration (C
₀
). Each of the aforementioned parameters influences the glucose sensor response. Experimental data compared with our numerical model showed a reasonable fit.