Detection of Peripheral Artery Stenosis Utilizing Wavelet Coherence Analysis

The peripheral arterial disease (PAD) pandemic affects over 200 million patients and is associated with a high risk of cardiovascular morbidity and mortality. The current screening method for PAD measures the ankle to brachial systolic pressure ratio and suffers from severe limitations. We present a novel modality for non-invasive monitoring of extremity perfusion, which employs miniature-sensors and impedance electrodes. Our novel indices of the peripheral perfusion wave dynamics were derived in the time and time-frequency domains over multiple cardiac cycles. The novel modality detected arterial-stenosis, induced by cuff compression, even with undetectable changes in the pressure.