Innovated noninvasive assessment of Parkinson's disease based on measurement of cerebral vasomotor reactivity with transcranial Doppler ultrasonography and capnography

In this paper, with the use of noninvasive TCD, Finapres, and Capnography, we investigated the cerebrovascular response to CO
₂
in PD patients and explored the interaction between cerebral autoregulation and ventilatory control by using nonlinear regression model. The results of these patients were compared with those of healthy subjects by examining their CBFV, CVMR (cerebrovascular Vasomotor Reactivity), and CVC
_i
(cerebrovascular conductance index) responses to CO
₂
. Statistical analysis of significance values between PD patients and healthy groups was evaluated. The results showed that the PD patients demonstrated a significantly lower level of CBFV
_max
(%) than the healthy elders with nonlinear regression model.