Application of Low Energy Proton Beam for Determination of Elemental Composition in Healthy and Pathological Tissues

In the aim of comparison of normal and pathological tissues two groups of samples were analysed. The first group consisted of gastric mucosa samples. Basing on the histological findings the samples were selected with different cancer cells count varying from very high value to the zero level (normal tissue). The second group of samples composed of blood serum, erythocytes, hairs and muscle tissue taken from patients with gall-blader or gastric cancer and those with noncancer gastro-intestinal tract disease. Using PIXE method the concentrations of the following elements were determined: P, S, Cl, K, Ca, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Se, Br, Rb, Sr and Pb. The significant differences of the content of various elements in normal and pathological tissue were observed.