Single-Molecule Detection Based on Graphene Cage-like Nanopores

In this paper, we report a novel solid-state nanopore sensor with small-sized graphene cage-structured nanopore prepared by using nanopore processing technology combined with two-dimensional thin film materials. We compare the differences between graphene nanopores and graphene cage-structured nanopores in DNA detection results. The results show that the reverse DNA molecule capture rate of graphene-caged nanopores is about 1.5 times higher than that of graphene nanopores at 600 mV. The simulation analysis shows that there is a significant difference in the potential distribution of the caged nanopores with different structures. This study is expected to further enrich the single-molecule detection means of solid-state nanopores and provide new ideas for different detection needs.