Development of a Measuring Transducer of the System for Personalized NIRS Diagnostics and Telemedical Control in Neurology

The advantages of near infrared spectroscopy determine the wide possibilities of its application in neurology. The method can be used together with other neuroimaging methods (PET, MRI/fMRI) as a part of neural network or classical machine learning model for the diagnosis of dementia and determination of its type. It is possible to use the NIRS system for multiple, repeated, patient-friendly telemedical control of the dynamics of the patient’s condition in a local medical center or while a home visit of a specialist for timely correction of provided treatment. This paper highlights the main aspects of the design of a system for personalized NIRS diagnostics and telemedical control of the patient’s condition in neurology and presents the development of a prototype of NIRS measuring transducer, according to medical and technical requirements. The advantages of the proposed electrical scheme of the measuring transducer are a compact design due to the use of a multi-frequency approach and the possibility to register the concentration of three chromophores such as oxy-, deoxyhemoglobin, oxidized cytochrome-c-oxidase which allows to reduce the number of unknown variables in the regression multimodal MRI-NIRS model for simultaneous assessment of cerebral blood flow velocity and oxygen consumption rate of brain tissues.