The Study of Raman Spectral Differences Between U87 Glioma Tumor Tissue and Normal Tissue

In this paper, the Raman spectra of tumor and normal region in U87 glioma tissue were measured by using a microscope system in the range of 300–1800 cm
^-1
, respectively. The results showed that there were apparent intensity difference between tumor and normal tissues, where the peaks were related to the reducing of the lipids metabolic pathways, and increase of the RNA and glycogen in tumor tissue region. These results demonstrated that Raman spectroscopy can diagnose glioma, which provided a promising tool for diagnosing mechanism of glioma.