Resolution Recovery by PSF Deconvolution on List Mode MLEM Reconstruction for Dynamic Cardiac SPECT System

This work presents improvement in imaging resolution by implementing spatial variant point spread function (SV-PSF) with list mode MLEM reconstruction for the DC-SPECT system being developed at MGH, Harvard. Results show that with PSF modeling applied, quality of the reconstructed image is improved, and DC-SPECT system can achieve a 4.5 mm central spatial resolution with average 795 counts/(s*Mbq). The results show substantial improvement over the gold standard GE Discovery 570c performance (spatial resolution 7 mm with an average 460 counts/s*MBq, central resolution 5.8 mm).