The DE-SPECT System: A Hyperspectral SPECT System for in Vivo 3-D Gamma-Ray Spectrometry of Molecular Theranostics

The Dynamic Extremity SPECT (DE-SPECT) system is a hyperspectral organ-dedicated SPECT system based on 1-cm thick Cadmium Zinc Telluride (CZT) imaging spectrometers and dynamic dual-field-of-view (FOV) compound-eye collimators. The objective of the project is to develop a non-invasive imaging technique for comprehensive assessment of peripheral vascular disease (PVD) in lower extremities.The DE-SPECT system is a stationary and high-performance SPECT system that offers an excellent energy performance (2.6 keV FWHM at 220 keV, 3.3 keV at 440 keV) over a wide energy range up to 600 keV, an optimized imaging geometry with a numerically-controlled dual-FOV aperture (offering 28-cm diameter FOV for dual-leg imaging and 16-cm diameter FOV for focused high-resolution and high-sensitivity imaging), and a relatively high sensitivity for multi-tracer SPECT imaging in the lower extremities. The system offers an unmatched ability to perform in vivo voxel-by-voxel gamma-ray spectrometry to derive the concentrations of multiple commonly used radiotracers (Tl-201, Tc-99m, I-123, In-111, etc.) and therapeutic radionuclides (Ac-225, Ra-223, and Lu-177, etc.) in user-selected targeted regions. This capability makes it particularly attractive for molecularly-guided interventions.