Medication Knowledge Graph Analysis Using the PageRank Algorithm

Electronic health records (EHRs) data from the US Department of Veterans Affairs (VA) show that many veterans have been treated with the Selective Serotonin Reuptake Inhibitors (SSRIs) class of antidepressant medications. It is crucial to study medications in association with other important clinical concepts to make better medication prescribing decisions and conduct better analyses of medication side effects and comorbidity. In this paper, we used PubMed’s knowledge graph and PageRank algorithm to identify important concepts related to three medications that belong to the SSRI class. Our preliminary research shows that the PageRank-based publication knowledge graph analysis approach is capable of extracting interesting clinical concepts related to antidepressant medications and has the potential to improve clinical decision-making.