Network and Node Analysis of Growth factor receptor-binding protein 10: Insulin Signaling Pathway Regulator

Type 2 diabetes is a multifactorial metabolic disorder characterized by reduced insulin secretion and pancreatic
$\beta$
-cells failure. The polygenic nature of T2D includes the regulation of various gene expression such as transcription factor 7-like 2 (TCF7L2), ATP-binding cassette transporter sub-family C member 8 (ABCC8), glucose transporter 2 (GLUT2), and growth factor receptor-binding protein 10 (GRB10) etc. GRB10 is an adaptor protein which regulates the various biological functions within the pancreas including cell differentiation and death. It also has a role in metabolic processes as it negatively regulates insulin signaling pathway and act as important target in the pathogenesis of T2D. Hence, it would be important to highlight the various interaction of GRB10 protein and molecular signaling pathways regulated by this gene along with other associated biomolecules which might helps to identify the biomarkers associated with T2D and may have therapeutic implications and promote pancreatic
$\beta$
-cells growth during development of T2D.