Design of a DNA Synthesis Chip for Data Storage with Ultra-High Throughput and Density Featuring Large-Scale Integrated Circuits and Microfluidic Confinement

This paper proposes a novel DNA synthesis chip design targeting data storage application, achieving ultrahigh throughput(10
⁷
) and unit density(10
⁷
/cm
²
) via the synergetic function of a dynamic random access memory (DRAM)-like integrated circuit (IC) and microfluidic confinement architecture. Through theoretical and simulation study, we verify individual addressability to 10
⁷
synthesis units by maintaining stable voltage output. We also demonstrate effective proton confinement through microfluidic structures at 10
⁷
/cm
²
unit density.