1. INTRODUCTION
An increase in respiratory diseases has been estimated in recent years and among them one of the most common is asthma [1]. Asthma is a chronic inflammatory disorder, and its distinctive feature is the airflow limitation due to airway obstruction, which may be reversible or permanent depending on the severity of the pathology. Airways obstruction is the result of an increase in the thickness of the bronchial wall together with a narrowing of the lumen of the airways. The combination of these structural changes is called airway remodeling [2]. Biomarkers of airway remodeling are needed to evaluate both the progression of disease and the effect of novel therapeutics. In this sense, computed tomography (CT) offers the possibility of qualitatively and quantitatively assessing airways morphology [1]. Although numerous image-processing methods have been developed for this purpose, research is still active for accurately measuring structural airways parameters and for achieving the most reliable parameters for diagnoses and follow-up.