An Empirical Approach of Developing Domain Based Ontology in the Field of Bioinformatics

From a macro viewpoint, it is essential to comprehend the similarities across human illnesses in order to identify underlying mechanisms at the microscopic level. Previous studies have shown that employing machine learning methods or merging many data sources can improve performance in sickness similarity measurement. However, there is currently a gap in the development of a useful framework for information extraction and integration from a range of biological data using deep learning models. We introduce CoGO, a Contrastive learning system that predicts commonalities in illnesses based on gene networks and ontology structure. Gene ontology (GO) and gene interaction network domain information is integrated into CoGO using graph deep learning models. Graph deep learning models are first used to encode gene and GO word features from independent graph structure data. Gene and GO characteristics are then mapped via a nonlinear projection to a shared embedding space. Next, by using cross-view contrastive loss to increase the agreement of related gene-GO links, meaningful gene representations are generated. Finally, to calculate disease similarity, CoGO computes the cosine similarity of sickness representation vectors derived from related gene embeddings.