Gold-Coated Phage Nanosomes For Ultrasound Mediated Breast Cancer Therapeutics

Ultrasound has been an excellent tool for various disease diagnoses over the last few decades. Due to its noninvasive properties, the FDA has approved it for therapeutic application in multiple diseases, leading to new avenues in precise drug delivery. Over the last decade, different organic and inorganic ultrasound-sensitive nanoparticles have been developed for disease theranostic applications. The present study reports the synthesis of novel phage-based gold-coated nanosomes for ultrasound-mediated cancer therapeutics. The synthesized nanosomes were evaluated for their size and morphology, and the ultrasound sensitivity. Nanosomes under ultrasound trigger has released the therapeutic drug mitoxantrone and generated significant ROS in 4T1 cells, which resulted in mitochondrial damage and cellular apoptosis, eventually causing cell death. In summary, the synthesized nanosomes were found to be potent ultrasound-responsive materials for cancer therapeutics.