Instrumentation development for 2D bioimpedance mapping with a Thin-Film-Transistor active matrix device

Multimodal biosensor active matrix devices, integrated with electronic circuits, are tremendously attractive for biomedical application. Actually, with these devices, multiple dye-free sensing techniques can be applied until single cell level, for real-time measurement and improved efficiency. Besides CMOS technology, the realization of these devices can be achieved with Thin-Film-Transistor (TFT) technology, with the advantage of transparency and 10 times larger scale sensing area. In this abstract, the authors present the instrumentation development to achieve 2D bioimpedance sensing with TFT-devices. First results are also shown. This development will be combined to electrophysiology measurements, already obtained previously, and optical observation to achieve a 2D multimodal sensing system to investigate cardiomyocyte cell culture from different aspects.