Relating Underlying Performance Objectives of Overground Walking to Observable Walking Mechanics using Predictive Musculoskeletal Simulations

There exists motor redundancy during human gait that allows individuals to perform the same task in different observable ways (i.e., with varied styles). However, how differences in observable walking mechanics depend on unique and underlying biomechanical objectives is unclear. As an example, these objectives could include metabolic energy consumption, sum of muscle activations, limb mechanical loading, balance and combinations thereof. In this study, we develop predictive neuromuscular simulations to investigate the relationships between these biomechanical objectives and observable mechanics during level walking. We simulated 3D normal walking of five healthy subjects, while optimizing each of the aforementioned objectives-resulting in 25 forward dynamics simulations for analysis. We compared the resulting joint kinematics and moments of different simulations. One of main findings suggests that decreased hip abduction angle is tightly related to when the regulation of dynamic balance (computed as whole-body angular momentum) is included in a movement cost function. We also find that increased joint moments are related to including metabolic cost (i.e., objectives associated with improving the energy economy of movement). Further, the timing of joint kinematics is adjusted for different performance objectives. These findings could guide the development of rehabilitation training and assistive devices that target specific individuals, tasks, and specific styles of movement.