An Integrated Framework of Projection and Attenuation Correction for Quantitative SPECT/CT Reconstruction

Quantitative SPECT imaging has become more and more common due to increasing demands in clinical[1]. With the development of SPECT/CT, quantification techniques for SPECT have also developed rapidly in recent years. However, the performance of the existing methods, such as reconstruction speed and quantification accuracy, needs further optimization and validation. In this work, we propose a new framework that can improve the reconstruction speed and quantification accuracy simultaneously. Experimental studies were conducted to evaluate the proposed method. A Jaszczak phantom was employed for general quality control purposes. Besides, reconstruction speed, spatial resolution and quantification accuracy were all evaluated. For typical 64×64× 64 cardiac imaging, one iteration reconstruction took only 0.13 s. Spatial resolution for the center and the peripheral point was <4.3 mm and <3.7 mm respectively. Furthermore, a NEMA torso phantom was scanned and reconstructed for quantification evaluation, and 10% relative error was achieved with the proposed reconstruction.