Synthesis of polymer-coated metal-organic frameworks for gene delivery

Gene therapy is on the cutting edge of modern medicine, thus delivery of gene of interest (GOI) is an ongoing challenging task. Here, we performed optimization of synthesis of polymer-coated metal-organic frameworks with magnetic core, aiming to improve their ability to be nucleic acid carriers. We varied different synthesis parameters to investigate their impact on DNA-binding capacity as well as on the ability of certain nanoparticles to be a vehicle for in vitro transfection.