Bio-informatics Sequence Alignment Technology Based on Estimate Algorithm

with the implementation of human genome project (HGP) and other projects, the accumulation rate of biological and related data is increasing explosively. In the past, the comparative study of biological sequences was mainly based on the theory of traditional statistics. There was great randomness and uncertainty in the processing of massive data and information, which was obviously disturbed and affected by human factors. This paper discusses the origin and development of estimation algorithm, summarizes the short sequence alignment algorithm, analyzes the sequence alignment problem, and compares the performance of the algorithm. The results show that the D algorithm uses less memory because it does not load the reference genome into memory to establish the index.