Effects of the Inhomogeneous Loading of Magnetic Nanoparticles in Thermoseeds for Bone Tumors Hyperthermia

Bone tumors can be treated by delivering local hyperthermia by exposing to a radiofrequency magnetic field implanted biomaterials loaded with magnetic nanoparticles. To date, the manufacturing of this kind magnetic thermoseeds can result in significantly inhomogeneous loading patterns, which can drastically affect the quality and outcome of the hyperthermia treatment. Beside this aspect, the problem of reliably assessing the specific absorption rate and the therapeutic potential of so-called magnetic scaffolds arise. This work deals with the investigation of the effects of inhomogeneous loading on the hyperthermia treatment of bone tumors. To this aim, numerical, multiphysics studies are carried out to elucidate if and how the magnetic nanoparticles distribution can affect the hyperthermia treatment.