Numerical simulation of cancer tissue eletroporation base on mesh transport network method

Electroporation-based therapies utilize intensive pulsed electric fields to destroy the electric shield and plasm insulation of the cellular membrane, which is promising in the non-thermal ablation of tumors. A simulation study to probe the membrane electroporation in the homogeneous prostate cancer tissue is presented. Mesh transport network method (MTNM) based on a two-dimensional Voronoi diagram is used to explore the ablation effect with different polarity and direction of pulsed electric fields. Simulation results suggest that, compared with bipolar electric field burst, more cell is electroporated under the action of unipolar electric field burst, and electroporation occurs faster in the cellular membrane perpendicular to the electric field. The study can be inspirational in the electrochemotherapy in irregularly shaped cells and complex pathological tissue.